Association between DNA ploidy and micronucleus frequency in chronic smokers and impact of smoking cessation

Autor(es)

Cruz, B. S. ^[1] ; Schwarzmeier, L. A. T. ^[1] ; Carvalho, B. F. D. C. ^[1] ; Alves, M. G. O. ^{[2, 1, 3]} ; Carta, C. F. L. ^[1] ; Balducci, I ^[4] ; Scholz, J. R. ^[5] ; Almeida, J. D. ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ Unesp, Inst Sci & Technol, Dept Biosci & Oral Diag, 777 Av Eng Francisco Jose Longo, BR-12245000 Sao Jose Dos Campos, SP - Brazil

^[2] Univ Mogi das Cruzes, Mogi Das Cruzes, SP - Brazil

^[3] Univ Anhembi Morumbi, Sao Jose Dos Campos, SP - Brazil

^[4] Sao Paulo State Univ Unesp, Inst Sci & Technol, Dept Social Sci & Pediat Dent, Sao Jose Dos Campos, SP - Brazil

^[5] Univ Sao Paulo, Med Sch, Univ Hosp, Heart Inst, Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: HUMAN & EXPERIMENTAL TOXICOLOGY; v. 40, n. 8, p. 1374-1382, AUG 2021.
• Citações Web of Science: 1

Resumo

Tobacco use may initiate the process of oral carcinogenesis with clinically undetectable changes. Smoking cessation may prevent its progression. The objective of this study was to evaluate the association between DNA ploidy and micronucleus (MN) frequency in chronic smokers. Three groups were evaluated: Smoker Group, Former Smoker Group and Control Group. Exfoliative cytology was performed on the lateral border of the tongue and mouth floor. MN and DNA ploidy analyses were performed, as well as the correlation between the variables. The data showed a difference between the groups for the total MN (p = 0.0227), and the Smoker group had the highest mean (4.22 +/- 4.12). The three groups did not differ statistically from each other on ploidy evaluation (p-value > 0.05). There was also an association between aneuploidy and increased MN frequency in the Former Smoker group (p = 0.0036). In conclusion, these results point out that there is a relationship between the frequency of MN and aneuploidy in former smokers. Moreover, smoking cessation, even for a short period of time, may promote the decrease of MN frequency caused by tobacco use. (AU)

• Processo FAPESP: 16/24047-4 - Associação da ploidia do DNA e a frequência de micronúcleos na mucosa bucal em pacientes fumantes crônicos
• Beneficiário: Beatriz Serralheiro da Cruz
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 13/09910-0 - Avaliação do efeito do tabagismo crônico e da abstinência na aneuploidia em células da mucosa bucal
• Beneficiário: Bruna Fernandes do Carmo Carvalho
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 12/05371-4 - Avaliação citogenética dos danos causados pelo tabagismo à mucosa bucal
• Beneficiário: Janete Dias Almeida
• Modalidade de apoio: Auxílio à Pesquisa - Regular