| Texto completo | |
| Autor(es): |
Nogueira, Jonatas E.
[1]
;
Amorim, Mateus R.
[2]
;
Pinto, Ana P.
[3]
;
da Rocha, Alisson L.
[4, 3]
;
da Silva, Adelino S. R.
[1, 3]
;
Branco, Luiz G. S.
[4, 2, 3]
Número total de Autores: 6
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Sch Phys Educ & Sports Ribeirao Preto, Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Dent Sch Ribeirao Preto, Dept Basic & Oral Biol, Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Sch Med Ribeirao Preto, Postgrad Program Rehabil & Funct Performance, Ribeirao Preto, SP - Brazil
[4] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Physiol, Ribeirao Preto, SP - Brazil
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Canadian Journal of Physiology and Pharmacology; v. 99, n. 8, p. 812-820, AUG 2021. |
| Citações Web of Science: | 0 |
| Resumo | |
Physical exercise-induced skeletal muscle damage may be characterized by increased oxidative stress, inflammation, and apoptosis which may be beneficial when exercise is regular, but it is rather harmful when exercise is exhaustive and performed acutely by unaccustomed individuals. Molecular hydrogen (H-2) has emerged as a potent antioxidant, anti-inflammatory, and anti-apoptotic agent, but its action on the deleterious effects of acute exhaustive exercise in muscle damage remain unknown. Therefore, we tested the hypothesis that H-2 decreases acute exhaustive exercise-induced skeletal muscle damage of sedentary rats. Rats ran to exhaustion on a sealed treadmill inhaling an H-2-containing mixture or the control gas. We measured oxidative stress (SOD, GSH, and TBARS), inflammatory (TNF-alpha, IL-1 beta, IL-6, IL-10, and NF-kappa B phosphorylation), and apoptotic (expression of caspase-3, Bcl-2, and HSP70) markers. Exercise caused no changes in SOD activity but increased TBARS levels. H-2 caused increases in exercise-induced SOD activity and blunted exercise-induced increased TBARS levels. We observed exercise-induced TNF-alpha and IL-6 surges as well as NF-kappa B phosphorylation, which were blunted by H-2. Exercise increased cleaved caspase-3 expression, and H-2 reduced this response. In conclusion, H-2 effectively downregulates muscle damage, reducing oxidative stress, inflammation, and apoptosis after acute exhaustive exercise performed by an unaccustomed organism. (AU) | |
| Processo FAPESP: | 17/09878-0 - Efeito da estimulação vagal durante desafio imune por LPS em ratos normotensos e espontaneamente hipertensos |
| Beneficiário: | Mateus Ramos Amorim |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 16/17681-9 - Alterações fisiopatológicas durante a inflamação sistêmica |
| Beneficiário: | Luiz Guilherme de Siqueira Branco |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 17/19869-8 - Mecanismos moleculares relacionados ao aumento do conteúdo hepático de gordura em resposta ao excesso de exercício físico |
| Beneficiário: | Ana Paula Pinto |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 17/12765-2 - Papel emergente da rev-erb-alfa nas adaptações moleculares a diferentes modelos de exercício físico |
| Beneficiário: | Alisson Luiz da Rocha |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |