Insulin Resistance as a Common Link Between Current Alzheimer's Disease Hypotheses

Autor(es)

Alves, Suelen Santos ^[1] ; Patricio da Silva-Junior, Rui Milton ^{[2, 3]} ; Servilha-Menezes, Gabriel ^[2] ; Homolak, Jan ^{[4, 5]} ; Salkovic-Petrisic, Melita ^{[4, 5]} ; Garcia-Cairasco, Norberto ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo FMRP USP, Dept Neurosci & Behav Sci, Ribeirao Preto Med Sch, Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo FMRP USP, Ribeirao Preto Med Sch, Dept Physiol, Ribeirao Preto, SP - Brazil

^[3] Univ Sao Paulo FMRP USP, Dept Internal Med, Ribeirao Preto Med Sch, Ribeirao Preto, SP - Brazil

^[4] Univ Zagreb, Dept Pharmacol, Sch Med, Zagreb - Croatia

^[5] Univ Zagreb, Croatian Inst Brain Res, Sch Med, Zagreb - Croatia

• Tipo de documento: Artigo de Revisão
• Fonte: JOURNAL OF ALZHEIMER'S DISEASE; v. 82, n. 1, p. 71-105, 2021.
• Citações Web of Science: 1

Resumo

Almost 115 years ago, Alois Alzheimer described Alzheimer's disease (AD) for the first time. Since then, many hypotheses have been proposed. However, AD remains a severe health public problem. The current medical approaches for AD are limited to symptomatic interventions and the complexity of this disease has led to a failure rate of approximately 99.6% in AD clinical trials. In fact, no new drug has been approved for AD treatment since 2003. These failures indicate that we are failing in mimicking this disease in experimental models. Although most studies have focused on the amyloid cascade hypothesis of AD, the literature has made clear that AD is rather a multifactorial disorder. Therefore, the persistence in a single theory has resulted in lost opportunities. In this review, we aim to present the striking points of the long scientific path followed since the description of the first AD case and the main AD hypotheses discussed over the last decades. We also propose insulin resistance as a common link between many other hypotheses. (AU)

• Processo FAPESP: 19/00849-2 - Mecanismos fisiopatológicos e moleculares de tumorigênese: abordagem baseada em plataformas de sequenciamento em escala genômica (NGS - Next-generation sequencing)
• Beneficiário: Rui Milton Patrício da Silva Junior
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 19/05957-8 - Epilepsias e comorbidades neuropsiquiátricas: caracterização dos efeitos do tratamento com canabidiol e HUF-101 em modelos experimentais in vivo e in vitro
• Beneficiário: Norberto Garcia Cairasco
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/50891-1 - INCT 2014: Translacional em Medicina
• Beneficiário: Jaime Eduardo Cecilio Hallak
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 19/02787-4 - Efeitos do canabidiol veiculado em nanoemulsão em ratos submetidos ao modelo químico de epilepsia do lobo temporal
• Beneficiário: Gabriel Servilha Menezes
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica