Associations between obesity-related gene expression in maternal and cord blood and newborn adiposity: findings from the Araraquara Cohort study

Autor(es)

Nakandakare, P. ^[1] ; Nicoletti, C. F. ^[2] ; Noronha, N. Y. ^[3] ; Nonino, C. B. ^[2] ; Argentato, P. P. ^[1] ; Dejani, N. N. ^[1] ; Luzia, L. A. ^[1] ; Rogero, M. M. ^[1] ; Rondo, P. H. C. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Publ Hlth, Nutr Dept, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Hlth Sci, Lab Nutrigen Studies, Ribeirao Preto - Brazil

^[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Internal Med, Ribeirao Preto - Brazil

• Tipo de documento: Artigo Científico
• Fonte: International Journal of Obesity; v. 45, n. 9, p. 1958-1966, SEP 2021.
• Citações Web of Science: 0

Resumo

Background/objectives Genes involved in the regulation of metabolism, adipose tissue deposition, inflammation, and the appetite-satiety axis may play an important role in fetal development, and possibly induce permanent metabolic changes and fat accumulation. In this study we investigated: (1) obesity-related gene expression in maternal and cord blood of overweight/obese and normal-weight pregnant women; (2) associations between obesity-related gene expression in maternal and cord blood; and (3) associations of gene expression in each of maternal and cord blood with newborn adiposity. Subjects/methods Twenty-five overweight/obese and 32 normal-weight pregnant women were selected from the Araraquara Cohort Study according to their pre-pregnancy BMI. Maternal and cord blood gene expression of LEPR, STAT3, PPARG, TLR4, IL-6, IL-10, FTO, MC4R, TNF-alpha, and NF kappa B were investigated by relative real-time PCR quantification. The body composition of the newborns was assessed by air displacement plethysmography. Associations between maternal and cord blood gene expression and markers of newborn adiposity (weight, BMI, and fat mass%) were explored by linear regression models controlling for maternal age, pre-pregnancy BMI, maternal gestational weight gain, gestational age, and newborn sex. Results There was higher TLR4, NF kappa B, and TNF-a expression, and lower IL-6 expression, in overweight/obese pregnant women and their respective newborns compared with normal-weight women and their newborns (p < 0.001). Maternal PPARG gene expression was associated with both weight and fat mass % of the newborns, and cord blood IL-10 expression was associated with BMI and fat mass %, controlling for confounders. Conclusion To our knowledge, this is the first study to evaluate the relationship of maternal and cord blood gene expression with adiposity markers of the newborn. Our results provide evidence for the contribution of maternal and cord blood gene expression-particularly maternal PPARG and TLR4 expression, and cord blood IL-10 expression-to newborn weight, BMI, and fat mass %. (AU)

• Processo FAPESP: 18/17824-0 - Perfil da metilação do DNA do binômio mãe-concepto no contexto da Obesidade materna e adiposidade fetal e neonatal
• Beneficiário: Perla Pizzi Argentato
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 17/07143-2 - Uma abordagem imunológica da relação entre adiposidade materna e do concepto nos períodos fetal, neonatal e no primeiro ano de vida
• Beneficiário: Naiara Naiana Dejani
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 15/03333-6 - Relação entre adiposidade materna e adiposidade do concepto nos períodos fetal, neonatal e no primeiro ano de vida: estudo prospectivo de base populacional
• Beneficiário: Patricia Helen de Carvalho Rondó
• Modalidade de apoio: Auxílio à Pesquisa - Temático