Cytotoxicity and effects of curcumin and cinnamaldehyde hybrids on biofilms of oral pathogens

Autor(es)

Dos Santos, Vanessa Rodrigues ^[1] ; Caiaffa, Karina Sampaio ^[1] ; de Oliveira, Warlley Campos ^[1] ; Pereira, Jesse Augusto ^[1] ; Abuna, Gabriel Flores ; Polaquini, Carlos Roberto ^{[2, 3]} ; Regasini, Luis Octavio ^[2] ; Guiotti, Aimee Maria ^[4] ; Duque, Cristiane ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Aracatuba Sch Dent, Dept Prevent & Restorat Dent, Aracatuba, SP - Brazil

^[2] Sao Paulo State Univ UNESP, Inst Biosci Humanities & Exact Sci, Dept Chem & Environm Sci, Sao Jose Do Rio Preto, SP - Brazil

^[3] Univ Campinas UNICAMP, Fac Dent Piracicaba, Dept Restorat Dent, Piracicaba, SP - Brazil

^[4] Sao Paulo State Univ UNESP, Aracatuba Sch Dent, Dept Dent Mat & Prosthodont, Aracatuba, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: BIOFOULING; v. 37, n. 6, p. 591-605, JUL 3 2021.
• Citações Web of Science: 1

Resumo

The objective of the study was to evaluate the cytotoxicity and effect of curcumin-cinnamaldehyde hybrids (CCHs) on the biofilm of oral pathogens. Of the 18 hybrids tested, nine had an inhibitory effect on at least one of the bacterial species tested, with minimal inhibitory and bactericidal concentrations ranging from 9 to 625 mu g ml(-1). CCH 7 promoted a potent inhibitory effect against all the bacterial species tested and better compatibility than chlorhexidine (CHX). CCH 7 also presented a similar or improved effect over that of CHX, causing a reduction in bacterial metabolism and viability in single and dual-species biofilms. CCH 7 reduced by 86% and 34% the viability of multispecies biofilms formed by collection and clinical strains. It can be concluded that CCH 7 was cytocompatible at the minimal inhibitory concentration, presented anti-biofilm action against oral pathogens, and could act as an antimicrobial agent for application in endodontics. (AU)

• Processo FAPESP: 17/05892-8 - Efeito citotóxico e ação antimicrobiana/antibiofilme de híbridos de curcumina e cinamaldeído sobre microrganismos de interesse endodôntico
• Beneficiário: Vanessa Rodrigues dos Santos
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 18/15083-2 - Síntese e avaliação biológica de isobavachalcona (IBC) e análogos como potenciais agentes contra a tuberculose
• Beneficiário: Luis Octávio Regasini
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/18330-0 - Preparação e avaliação biológica de híbridos curcumina-cinamaldeído como inibidores da divisão celular bacteriana
• Beneficiário: Luis Octávio Regasini
• Modalidade de apoio: Auxílio à Pesquisa - Regular