Extracellular miRNAs in redox signaling: Health, disease and potential therapies

Autor(es)

Ruiz, Gabriel Palermo ^[1] ; Camara, Henrique ^[1] ; Fazolini, Narayana P. B. ^[1] ; Mori, Marcelo A. ^{[1, 2, 3]}

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Inst Biol, Dept Biochem & Tissue Biol, Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Expt Med Res Cluster EMRC, Campinas, SP - Brazil

^[3] Univ Estadual Campinas, Obes & Comorbid Res Ctr OCRC, Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Free Radical Biology and Medicine; v. 173, p. 170-187, SEP 2021.
• Citações Web of Science: 2

Resumo

Extracellular microRNAs (miRNAs) have emerged as important mediators of cell-to-cell communication and intertissue crosstalk. MiRNAs are produced by virtually all types of eukaryotic cells and can be selectively packaged and released to the extracellular medium, where they may reach distal cells to regulate gene expression cell non-autonomously. By doing so, miRNAs participate in integrative physiology. Oxidative stress affects miRNA expression, while miRNAs control redox signaling. Disruption in miRNA expression, processing or release to the extracellular compartment are associated with aging and a number of chronic diseases, such as obesity, type 2 diabetes, neurodegenerative diseases and cancer, all of them being conditions related to oxidative stress. Here we discuss the interplay between redox balance and miRNA function and secretion as a determinant of health and disease states, reviewing the findings that support this notion and highlighting novel and yet understudied venues of research in the field. (AU)

• Processo FAPESP: 17/23920-9 - Screening and Characterization of Circulating Molecules that Affect Energy Expenditure
• Beneficiário: Raissa Guimarães Ludwig
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• Processo FAPESP: 17/01184-9 - CAMeLEOm: análise entre espécies dos efeitos metabólicos, na expectativa de vida e ômicas de miméticos de restrição dietética
• Beneficiário: Marcelo Alves da Silva Mori
• Linha de fomento: Auxílio à Pesquisa - Temático
• Processo FAPESP: 17/01339-2 - Desvendando Mecanismos de Controle da Longevidade por RNAs Móveis
• Beneficiário: Henrique Camara
• Linha de fomento: Bolsas no Brasil - Doutorado
• Processo FAPESP: 18/21635-8 - Estudo do papel do miR-203-3p no metabolismo do tecido adiposo e no desenvolvimento de doenças metabólicas em camundongos
• Beneficiário: Gabriel Palermo Ruiz
• Linha de fomento: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 17/07975-8 - Explorando o papel de miRNAs circulantes derivados do tecido adiposo nos efeitos benéficos do treinamento físico
• Beneficiário: Marcelo Alves da Silva Mori
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