| Texto completo | |
| Autor(es): Mostrar menos - |
Kirschnick, Laura Borges
[1]
;
Silveira, Felipe Martins
[1]
;
Schuch, Lauren Frenzel
[1]
;
Fonseca, Felipe Paiva
[2]
;
Martins, Marco Antonio Trevizani
[3]
;
Lopes, Marcio Ajudarte
[1]
;
Santos-Silva, Alan Roger
[1]
;
Carrard, Vinicius Coelho
[3]
;
dos Santos, Jean Nunes
[4]
;
Vargas, Pablo Agustin
[1]
;
Wagner, Vivian Petersen
[3, 1]
;
Martins, Manoela Domingues
[3, 1]
Número total de Autores: 12
|
| Afiliação do(s) autor(es): | [1] Univ Estadual Campinas, Piracicaba Dent Sch, Oral Diag Dept, Piracicaba, SP - Brazil
[2] Univ Fed Minas Gerais, Sch Dent, Dept Oral Surg & Pathol, Belo Horizonte, MG - Brazil
[3] Univ Fed Rio Grande do Sul, Sch Dent, Dept Oral Pathol, Porto Alegre, RS - Brazil
[4] Univ Fed Bahia, Sch Dent, Dept Pathol, Postgrad Program Dent & Hlth, Salvador, BA - Brazil
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo de Revisão |
| Fonte: | JOURNAL OF ORAL PATHOLOGY & MEDICINE; v. 50, n. 8, p. 741-749, SEP 2021. |
| Citações Web of Science: | 1 |
| Resumo | |
Background The aim of the present systematic review was to analyze the available data regarding acinic cell carcinoma of the oral and maxillofacial region. Methods A search strategy was performed using PubMed, Web of Science, Scopus, and Embase electronic databases. Results Available data revealed a slight female preference (54.73%) and a mean age at diagnosis of 47.51 +/- 19.85 years. The parotid glands (67.72%) were most frequently affected, and most cases were asymptomatic (69.54%). A microcystic histopathological pattern was reported in 21.56% of the cases, and the Periodic acid-Schiff was the staining method most frequently used, after the hematoxylin and eosin staining, in the tumors analyzed. The lesions were mainly treated by surgical removal (72.32%). Recurrence was reported in 81 cases (27.83%) and metastasis in 100 (42.91%). Statistical data analysis revealed that tumors located in major salivary glands and exhibiting high-grade histology were associated with local recurrence (P = .01). In addition, the patients older than 57 years, lesions with bone involvement, the high-grade tumors and the cases with a history of recurrence and metastasis were associated with a lower overall survival (P < .05). Conclusion By assembling all eligible cases in the literature, the present systematic review determined the most common clinicopathological profile of acinic cell carcinoma and the most relevant prognostic factors in a distinctly representative sample. The survey demonstrated the importance of considering the histopathological grading in order to better define the treatment for each case. (AU) | |
| Processo FAPESP: | 16/21785-4 - Relação da via de sinalização BDNF/TRKB com a agressividade e perfil de células tronco tumorais de neoplasias malignas de glândula salivar |
| Beneficiário: | Vivian Petersen Wagner |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |