Long-term stability of the cortical volumetric profile and the functional human connectome throughout childhood and adolescence

Autor(es):Mostrar menos -

Sato, Joao Ricardo ^{[1, 2, 3]} ; Biazoli, Claudinei Eduardo ^{[4, 3]} ; Zugman, Andre ^{[1, 2]} ; Pan, Pedro Mario ^{[1, 2]} ; Arantes Bueno, Ana Paula ^[3] ; Moura, Luciana Monteiro ^{[1, 2, 3]} ; Gadelha, Ary ^{[1, 2]} ; Picon, Felipe Almeida ^{[2, 5, 6]} ; Amaro Jr, Edson ; Salum, Giovanni Abrahao ^{[5, 7, 6]} ; Constantino Miguel, Euripedes ^{[8, 7]} ; Rohde, Luis Augusto ^{[5, 7, 6]} ; Bressan, Rodrigo Affonseca ^{[1, 7]} ; Jackowski, Andrea Parolin ^{[1, 7]}

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo UNIFESP, Interdisciplinary Lab Clin Neurosci LiNC, Sao Paulo - Brazil

^[2] Natl Inst Dev Psychiat Children & Adolescents CNP, Sao Paulo - Brazil

^[3] Univ Fed ABC, Ctr Math Comp & Cognit, Av Estados, 5001 Bairro Bangu, BR-09210580 Santo Andre, SP - Brazil

^[4] Queen Mary Univ London, Dept Biol & Expt Psychol, London - England

^[5] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Dev Psychiat Program, Porto Alegre, RS - Brazil

^[6] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, ADHD Outpatient Program, Porto Alegre, RS - Brazil

^[7] Amaro Jr, Jr., Edson, Natl Inst Dev Psychiat Children & Adolescents CNP, Sao Paulo - Brazil

^[8] Univ Sao Paulo, Sch Med, Dept Psychiat, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: European Journal of Neuroscience; v. 54, n. 6 SEP 2021.
• Citações Web of Science: 0

Resumo

There is compelling evidence showing that between-subject variability in several functional and structural brain features is sufficient for unique identification in adults. However, individuation of brain functional connectomes depends on the stabilization of neurodevelopmental processes during childhood and adolescence. Here, we aimed to (1) evaluate the intra-subject functional connectome stability over time for the whole brain and for large scale functional networks and (2) determine the long-term identification accuracy or `fingerprinting' for the cortical volumetric profile and the functional connectome. For these purposes, we analysed a longitudinal cohort of 239 children and adolescents scanned in two sessions with an interval of approximately 3 years (age range 6-15 years at baseline and 9-18 years at follow-up). Corroborating previous results using short between-scan intervals in children and adolescents, we observed a moderate identification accuracy (38%) for the whole functional profile. In contrast, identification accuracy using cortical volumetric profile was 95%. Among the large-scale networks, the default-mode (26.8%), the frontoparietal (23.4%) and the dorsal-attention (27.6%) networks were the most discriminative. Our results provide further evidence for a protracted development of specific individual structural and functional connectivity profiles. (AU)

• Processo FAPESP: 18/21934-5 - Estatística de redes: teoria, métodos e aplicações
• Beneficiário: André Fujita
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 16/19376-9 - Integridade estrutural e funcional do circuito de Papez e sua relação com a simtomatologia na Esclerose Lateral Amiotrófica
• Beneficiário: Ana Paula Arantes de Andrade Bueno
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 13/08531-5 - Coorte de alto risco para transtornos psiquiátricos na infância: seguimento de neuroimagem após 3 anos
• Beneficiário: Andrea Parolin Jackowski
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/50917-0 - INCT 2014: psiquiatria do desenvolvimento para crianças e adolescentes
• Beneficiário: Eurípedes Constantino Miguel Filho
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 18/04654-9 - Séries temporais, ondaletas e dados de alta dimensão
• Beneficiário: Pedro Alberto Morettin
• Modalidade de apoio: Auxílio à Pesquisa - Temático