Molecular Networking Discloses the Chemical Diversity of Flavonoids and Selaginellins in Selaginella convoluta

Autor(es)

Santos Reginaldo, Fernanda Priscila ^[1] ; Pires Bueno, Paula Carolina ^{[2, 3]} ; de Matos Costa, Isabelly Cristina ^[1] ; Roque, Alan de Araujo ^[4] ; Fett-Neto, Arthur Germano ^{[5, 6]} ; Cavalheiro, Alberto Jose ^[7] ; Giordani, Raquel Brandt ^[1]

Afiliação do(s) autor(es)

^[1] Fed Univ Rio Grande do Norte UFRN, Dept Pharm, Gal Gustavo Cordeiro de Farias St S-N, BR-59012570 Natal, RN - Brazil

^[2] Max Planck Inst Mol Plant Physiol, Potsdam - Germany

^[3] Univ Sao Paulo FCFRP USP, Fac Pharmaceut Sci Ribeirao Preto, Ribeirao Preto, SP - Brazil

^[4] Dunas Pk Herbarium, Inst Sustainable Dev & Environm, Natal, RN - Brazil

^[5] Fed Univ Rio Grande do Sul UFRGS, Ctr Biotechnol, Lab Plant Physiol, Porto Alegre, RS - Brazil

^[6] Fed Univ Rio Grande do Sul UFRGS, Dept Bot, Porto Alegre, RS - Brazil

^[7] Sao Paulo State Univ UNESP, Inst Chem, Araraquara, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Planta Medica; v. 87, n. 01/02, p. 113-123, FEB 2021.
• Citações Web of Science: 0

Resumo

Selaginella convoluta is a desiccation tolerant plant native to the Brazilian semiarid region (Caatinga), endowed with an effective drought resistance mechanism. As part of our research efforts to understand the chemical diversity of S. convoluta, dehydrated (harvested in their natural habitat in the dry season) and hydrated (plant acclimated in a laboratory after rehydration) specimens were analyzed by HR-LC-ESI-MS/MS followed by a structural annotation on the Global Natural Products Social Molecular Networking Web platform. The molecular networking approach allowed for putative annotation of 39 metabolites, mainly selaginellins and flavonoids. Based on MS/MS data, three unprecedented selaginellins were annotated: 29-hydroxy selaginellin O, 29-hydroxy selaginellin A, and 4-[{[}2-(4-hydrophenyl)-6-{[}2-(4-hydroxyphenyl)ethynyl]phenyl](4-oxocy clohexa-2,5-dien-1-ylidene)methyl]benzaldehyde. Th results pointed out that valuable scientific knowledge can be obtained from studies conducted with plants in their natural habitat by allowing a more realistic profile of chemical diversity. The present study adds new information on specialized metabolites of S. convoluta , mainly flavonoids and selaginellins, and highlights the species as an untapped source of chemobiodiversity from Caatinga. (AU)

• Processo FAPESP: 14/50926-0 - INCT 2014: biodiversidade e produtos naturais
• Beneficiário: Vanderlan da Silva Bolzani
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Temático
• Processo FAPESP: 19/08477-7 - Análise integrada do metabolismo de Glycine max em resposta ao estresse hídrico
• Beneficiário: Paula Carolina Pires Bueno
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado
• Processo FAPESP: 17/19702-6 - Abordagens ômicas integradas para a avaliação da dinâmica micromolecular fenotípica de cultivares de Glycine max (soja) geneticamente modificados com vistas a tolerância à estresses hídricos
• Beneficiário: Paula Carolina Pires Bueno
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado