Nanocellulose/palygorskite biocomposite membranes for controlled release of metronidazole

Autor(es)

Meneguin, Andreia ^[1] ; Pacheco, Guilherme ^[2] ; Silva, Jhonatan Miguel ^[2] ; de Araujo, Francisca Pereira ^[3] ; Silva-Filho, Edson Cavalcanti ^[3] ; Bertolino, Luiz Carlos ^[4] ; Barud, Hernane da Silva ^[2]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Drugs & Med, Rodovia Araraquara Jau, Km 1, Campus Ville, BR-14800903 Araraquara, SP - Brazil

^[2] Centro Univ Araraquara, Res Ctr Biotechnol, BR-14801340 Araraquara, SP - Brazil

^[3] Univ Fed Piaui, Interdisciplinary Lab Adv Mat, LIMAV, Campus Univ Ministro Petronio Portella, BR-64049550 Teresina, Piaui - Brazil

^[4] Ctr Mineral Technol, Rio De Janeiro - Brazil

• Tipo de documento: Artigo Científico
• Fonte: International Journal of Biological Macromolecules; v. 188, p. 689-695, OCT 1 2021.
• Citações Web of Science: 0

Resumo

The incorporation of drugs in nanocomposites can be considered a potential strategy for controlled drug release. In this study, a nanocomposite based on bacterial cellulose and the palygorskite clay (BC/PLG) was produced and loaded with metronidazole (MTZ). The samples were characterized using X-ray diffraction (XRD) Spectroscopy, thermal analysis (TG/DTG) and Scanning Electron Microscopy (SEM). The barrier properties were determined to water vapor permeability (WVP). Adsorption tests with PLG were performed using MTZ and drug release profile of the membranes was investigated. The results indicated that PLG increased the crystallinity of the nano composites, and greater thermal stability when PLG concentration was 15.0% (BC/PLG15) was observed. WVP of the samples also varied, according to the clay content. Adsorption equilibrium was achieved from 400 mg/L of the PLG and a plateau in the MTZ release rates from BC/PLG was observed after 30 min. Therefore, the results of this study show the potential of these nanocomposite membranes as a platform for controlled drug release. (AU)

• Processo FAPESP: 13/07793-6 - CEPIV - Centro de Ensino, Pesquisa e Inovação em Vidros
• Beneficiário: Edgar Dutra Zanotto
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 19/19817-3 - Sistemas biorresponsivos baseados em amido retrogradado/pectina acrescidos de nanofibras de celulose como estratégia para liberação colônica do 5-ASA no tratamento da Doença Inflamatória Intestinal
• Beneficiário: Andréia Bagliotti Meneguin
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 18/25512-8 - Plataforma para Cultura de Células Baseada em Biocelulose
• Beneficiário: Hernane da Silva Barud
• Modalidade de apoio: Auxílio à Pesquisa - Regular