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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Retroperitoneal adipose tissue denervation improves cardiometabolic and autonomic dysfunction in a high fat diet model

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Autor(es):
Garcia, Michelle L. [1] ; Milanez, Maycon I. O. [1] ; Nishi, Erika E. [1] ; Sato, Alex Y. S. [1] ; Carvalho, Polliane M. [2] ; Nogueira, Fernando N. [2] ; Campos, Ruy R. [1] ; Oyama, Lila M. [1] ; Bergamaschi, Cassia T. [1]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Dept Physiol, Escola Paulista Med, Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Odontol, Dept Biomat & Oral Biol, Sao Paulo - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Life Sciences; v. 283, OCT 15 2021.
Citações Web of Science: 0
Resumo

Sympathetic vasomotor overactivity is a major feature leading to the cardiovascular dysfunction related to obesity. Considering that the retroperitoneal white adipose tissue (rWAT) is an important fat visceral depot and receives intense sympathetic and afferent innervations, the present study aimed to evaluate the effects evoked by bilateral rWAT denervation in obese rats. Male Wistar rats were fed with HFD for 8 consecutive weeks and rWAT denervation was performed at the 6th week. Arterial pressure, splanchnic and renal sympathetic vasomotor nerve activities were assessed and inflammation and the components of the renin -angiotensin system were evaluated in different white adipose tissue depots. HFD animals presented higher serum levels of leptin and glucose, an increase in arterial pressure and splanchnic sympathetic nerve activity; rWAT denervation, normalized these parameters. Pro-inflammatory cytokines levels were significantly increased, as well as RAAS gene expression in WAT of HFD animals; rWAT denervation significantly attenuated these changes. In conclusion, HFD promotes vasomotor sympathetic overactivation and inflammation with repercussions on the cardiovascular system. In conclusion, the neural communication between WAT and the brain is fundamental to trigger sympathetic vasomotor activation and this pathway is a possible new therapeutic target to treat obesityassociated cardiovascular dysfunction. (AU)

Processo FAPESP: 18/02671-3 - Ações funcionais e moleculares do nervo renal na doença renal crônica experimental
Beneficiário:Cassia Marta de Toledo Bergamaschi
Modalidade de apoio: Auxílio à Pesquisa - Regular