Doped Plasmonic Zinc Oxide Nanoparticles with Near-Infrared Absorption for Antitumor Activity

Autor(es)

Rissi, Nathalia Cristina ^[1] ; Comparetti, Edson J. ^[1] ; Estevao, Bianca Martins ^[1] ; Mastelaro, Valmor Roberto ^[2] ; Zucolotto, Valtencir ^{[1, 3]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sao Carlos Inst Phys, Nanomed & Nanotoxicol Grp, BR-13566590 Sao Carlos - Brazil

^[2] Univ Sao Paulo, Sao Carlos Inst Phys, Grp Nanomat & Adv Ceram, BR-13563120 Sao Carlos - Brazil

^[3] Univ Sao Paulo, Inst Adv Studies, BR-13566590 Sao Carlos - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ACS APPLIED NANO MATERIALS; v. 4, n. 9, p. 9779-9789, SEP 24 2021.
• Citações Web of Science: 0

Resumo

Plasmonic nanoparticles (NPs) have been extensively investigated as active materials for application in the optoelectronics, photocatalysis, and electrochemistry fields. In particular, doped metal oxides have attracted significant interest because of their optical and electrical properties. In this study, we investigated the influence of aluminum, gallium, and indium on the doping process of zinc oxide (ZnO) NPs. Physicochemical characterization revealed that, upon doping, ZnO NPs exhibited enhanced optoelectronic properties, including absorption in the near-infrared region. Lattice defects, such as vacancies and interstitials in the ZnO NPs crystal lattice, were also introduced by doping, changing the optical properties, and generating emission in the green-yellow, blue-violet, and orange-red band regions. We also investigated the ability of the ZnO NPs to induce cell death in human tumor cell lines and in a healthy cell line in vitro. (AU)

• Processo FAPESP: 18/12670-4 - Síntese de nanocarreadores lipídicos para modulação de células tumorais e imunocompetentes
• Beneficiário: Edson José Comparetti
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 17/22056-9 - Nanossistemas contendo "esponja" de prótons/nanopartículas de ouro para aplicação em condições de hipoxia tumoral
• Beneficiário: Bianca Martins Estevão
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 20/00124-5 - Nanomateriais funcionalizados para aplicação em terapias contra o câncer
• Beneficiário: Valtencir Zucolotto
• Modalidade de apoio: Auxílio à Pesquisa - Regular