Multi-omic strategies applied to the study of pharmacoresistance in mesial temporal lobe epilepsy

Autor(es)

Bruxel, Estela M. ^{[1, 2]} ; do Canto, Amanda M. ^{[1, 2]} ; Bruno, Danielle C. F. ^{[1, 2]} ; Geraldis, Jaqueline C. ^{[1, 2]} ; Lopes-Cendes, Iscia ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Brazilian Inst Neurosci & Neurotechnol BRAINN, Campinas - Brazil

^[2] Univ Estadual Campinas, UNICAMP, Dept Translat Med, Sch Med Sci, Tessalia Vieira Camargo 126, BR-13083887 Campinas, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: EPILEPSIA OPEN; OCT 2021.
• Citações Web of Science: 0

Resumo

Mesial temporal lobe epilepsy (MTLE) is the most common type of focal epilepsy in adults, and hippocampal sclerosis (HS) is a frequent histopathological feature in patients with MTLE. Pharmacoresistance is present in at least one-third of patients with MTLE with HS (MTLE+HS). Several hypotheses have been proposed to explain the mechanisms of pharmacoresistance in epilepsy, including the effect of genetic and molecular factors. In recent years, the increased knowledge generated by high-throughput omic technologies has significantly improved the power of molecular genetic studies to discover new mechanisms leading to disease and response to treatment. In this review, we present and discuss the contribution of different omic modalities to understand the basic mechanisms determining pharmacoresistance in patients with MTLE+HS. We provide an overview and a critical discussion of the findings, limitations, new approaches, and future directions of these studies to improve the understanding of pharmacoresistance in MTLE+HS. However, it is important to point out that, as with other complex traits, pharmacoresistance to anti-seizure medications is likely a multifactorial condition in which gene-gene and gene-environment interactions play an important role. Thus, studies using multidimensional approaches are more likely to unravel these intricate biological processes. (AU)

• Processo FAPESP: 19/25948-3 - Análise de sinaptossomos isolados do hipocampo de pacientes com Epilepsia Do Lobo Temporal Mesial utilizando ferramentas de proteômica e metabolômica
• Beneficiário: Amanda Morato Do Canto
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 20/06168-4 - Avaliação do papel de regiões regulatórias genômicas em cis nos mecanismos da Epilepsia do Lobo Temporal Mesial associada à Esclerose Hipocampal
• Beneficiário: Jaqueline Cruz Geraldis
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 13/07559-3 - Instituto Brasileiro de Neurociência e Neurotecnologia - BRAINN
• Beneficiário: Fernando Cendes
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 18/03254-7 - ESTUDO DE ASSOCIAÇÃO DE VARREDURA GENÔMICA BASEADA NA EXPRESSÃO GÊNICA (eGWAS) EM EPILEPSIA DE LOBO TEMPORAL MESIAL
• Beneficiário: Estela Maria Bruxel
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 17/26167-0 - Detecção de DNA circulante metilado como biomarcador não invasivo para identificação de pacientes com epilepsia do lobo temporal mesial e acidente vascular cerebral isquêmico
• Beneficiário: Danielle do Carmo Ferreira Bruno
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado