The effects of treadmill exercise in animal models of Parkinson's disease: A systematic review

Autor(es)

Ferreira, Ana Flavia F. ^[1] ; Binda, Karina Henrique ^{[2, 3]} ; Real, Caroline Cristiano ^{[4, 3]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Lab Cellular Neurobiol, Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, Lab Funct Neuroanat Pain, Sao Paulo, SP - Brazil

^[3] Aarhus Univ, Translat Neuropsychiat Unit TNU, Aarhus - Denmark

^[4] Univ Sao Paulo, Fac Med FMUSP, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS; v. 131, p. 1056-1075, DEC 2021.
• Citações Web of Science: 0

Resumo

Parkinson's disease (PD) is a progressive disabling brain disorder. Physical exercise has been shown to alleviate the symptoms of PD and, consequently, improve patient quality of life. Exercise mechanisms involved in beneficial effects on PD have been widely investigated. This study aims to systematically review the literature on the use of treadmill exercise in PD animal models. The study was conducted according to Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA). Searches were conducted in MEDLINE, EMBASE, and ISI databases. In total, 78 studies were included. The dopaminergic system, behavior, neuroplasticity, neuroinflammation, mitochondria, and musculoskeletal systems were some of the outcomes evaluated by the selected studies. Based on the systematic review center for laboratory animal experimentation (SYRCLE) RoB tool, the methodologies revealed a high risk of bias and lack of information about study design, which needs attention for data reproducibility. This review can guide future studies that aim to fill existing gaps regarding the effects of treadmill exercise in PD animal models. (AU)

• Processo FAPESP: 18/25204-1 - Papel dos sistemas opióides, cannabinóides, dopamina e neuroinflamação sobre o limiar de dor modulado pelo exercício físico em um modelo de Doença de Parkinson em rato utilizando substâncias radioativas.
• Beneficiário: Karina Henrique Binda
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Mestrado
• Processo FAPESP: 20/02109-3 - Participação do canal TRPM2 na neurodegeneração e ativação microglial no modelo da Doença de Parkinson induzido por 6-hidroxidopamina
• Beneficiário: Ana Flávia Fernandes Ferreira
• Modalidade de apoio: Bolsas no Brasil - Doutorado