meso-Tetra-(4-pyridyl)porphyrin/palladium(ii) complexes as anticancer agents

Autor(es)

Alves, Kamilla M. ^[1] ; Honorato, Joao ^{[2, 3]} ; Liao, Luciano M. ^[1] ; Velozo-Sa, Vivianne S. ^[4] ; Guedes, Adriana P. M. ^[3] ; Dutra, Jocely de L. ^[3] ; Ayalla, Alejando P. ^[5] ; Ellena, Javier ; Batista, Alzir A. ^{[3, 1]} ; Goncalves, Pablo J. ^{[6, 1]}

Afiliação do(s) autor(es)

^[1] Univ Fed Goias, Inst Chem, Goiania, Go - Brazil

^[2] Univ Sao Paulo, Sao Carlos Inst Phys, Sao Carlos, SP - Brazil

^[3] Univ Fed Sao Carlos, Dept Chem, Sao Carlos, SP - Brazil

^[4] Univ Fed Goias, Inst Biol Sci, Goiania, Go - Brazil

^[5] Univ Ceara, Dept Phys, Fortaleza, CE - Brazil

^[6] Univ Fed Goias, Inst Phys, Goiania, Go - Brazil

• Tipo de documento: Artigo Científico
• Fonte: DALTON TRANSACTIONS; v. 50, n. 44 SEP 2021.
• Citações Web of Science: 0

Resumo

This study reports the synthesis, structural characterization and cytotoxic activity of four new palladium/pyridylporphyrin complexes, with the general formula [TPyP{[}PdCl(P-P)](4)](PF6)(4), where P-P is 1,2-bis(diphenylphosphino)ethane (dppe), 1,3-bis(diphenylphosphino)propane (dppp), 1,2-bis(diphenylphosphino)butane (dppb) or 1,1 `-bis(diphenylphosphino)ferrocene (dppf). The complexes were characterized by elemental analysis, and by FT-IR, UV/Vis, H-1 and P-31[H-1] NMR (1D/2D) spectroscopy. The slow evaporation of a methanolic solution of [TPyP{[}PdCl(dppb)](4)](PF6)(4) (in an excess of NaBF4 salt) resulted in single crystals suitable for X ray diffraction, allowing the determination of the tridimensional structure of this complex, which crystallized in the P2(1)/a space group. The cytotoxicity of the complexes against MDA-MB-231 (breast cancer cells) and MCF-10A (non-tumor breast cancer cells), was determined by the colorimetric MTT method, which revealed that all four complexes show selective indexes close to 1.2, lower than that of cisplatin for the same cells (12.12). The interaction of the complexes with CT-DNA was evaluated by UV-visible and viscosity measurements and it was determined that the complexes interact moderately with CT-DNA, probably by H-bonding/pi-pi stacking and electrostatic interactions. (AU)

• Processo FAPESP: 21/02522-0 - EMU Concedido no processo 2017/15850-0: Synergy-S
• Beneficiário: Eduardo Ernesto Castellano
• Modalidade de apoio: Auxílio à Pesquisa - Programa Equipamentos Multiusuários
• Processo FAPESP: 21/04876-4 - Estudos sobre estrutura & atividade de complexos de RuII/areno/mercaptoligantes frente ao câncer
• Beneficiário: João Honorato de Araujo Neto
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 18/19342-2 - Complexos metalicos com ligantes derivados da lausona e aciltioureas, com potenciais atividades anticancerígenas: estudos in vitro e in vivo
• Beneficiário: Alzir Azevedo Batista
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/15850-0 - Difração de raios X como ferramenta no desenvolvimento de potenciais fármacos
• Beneficiário: Eduardo Ernesto Castellano
• Modalidade de apoio: Auxílio à Pesquisa - Temático