Fitting pieces into the puzzle: The impact of titanium-based dental implant surface modifications on bacterial accumulation and polymicrobial infections

Autor(es)

Costa, Raphael C. ^[1] ; Nagay, Bruna E. ^[1] ; Bertolini, Martinna ^[2] ; Costa-Oliveira, Barbara E. ^{[1, 3]} ; Sampaio, Aline A. ^[4] ; Retamal-Valdes, Belen ^[5] ; Shibli, Jamil A. ^[5] ; Feres, Magda ^[5] ; Barao, Valentim A. R. ^[1] ; Souza, Joao Gabriel S. ^{[5, 1, 6]}

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Prosthodont & Periodontol, UNICAMP, Limeira Ave 901, BR-13414903 Piracicaba, SP - Brazil

^[2] Univ Connecticut, Dept Oral Hlth & Diagnost Sci, Hlth Ctr, 263 Farmington Ave, Farmington, CT - USA

^[3] Univ Ceuma UNICEUMA, Grad Program Dent, 01 Josue Montello St, BR-65075120 Sao Luis, Maranhao - Brazil

^[4] Fed Univ Minas Gerais UFMG, Dept Clin Pathol & Dent Surg, 6627 Antonio Carlos Ave, BR-31270901 Belo Horizonte, MG - Brazil

^[5] Univ Guarulhos, Dent Res Div, BR-07023070 Guarulhos, SP - Brazil

^[6] Fac Ciencias Odontol FCO, Dent Sci Sch, 20 Waldomiro Marcondes Oliveira Ave, BR-39401303 Montes Claros, MG - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ADVANCES IN COLLOID AND INTERFACE SCIENCE; v. 298, DEC 2021.
• Citações Web of Science: 0

Resumo

Polymicrobial infection is the main cause of dental implant failure. Although numerous studies have reported the ability of titanium (Ti) surface modifications to inhibit microbial adhesion and biofilm accumulation, the majority of solutions for the utilization of Ti antibacterial surfaces have been testedin in vitro and animal models, with only a few developed surfaces progressing into clinical research. Motivated by this huge gap, we critically reviewed the scientific literature on the existing antibacterial Ti surfaces to help understand these surfaces' impact on the ``puzzle{''} of undesirable dental implant-related infections. This manuscript comprises three main sections: (i) a narrative review on topics related to oral biofilm formation, bacterial-implant surface interactions, and on how implant-surface modifications can influence microbial accumulation; (ii) a critical evidence-based review to summarize pre-clinical and clinical studies in an attempt to ``fit pieces into the puzzle{''} to unveil the best way to reduce microbial loads and control polymicrobial infection around dental implants showed by the current in vivo evidence; and (iii) discussion and recommendations for future research testing emerging antibacterial implant surfaces, connecting basic science and the requirements for future clinical translation. The findings of the present review suggest no consensus regarding the best available Ti surface to reduce bacterial colonization on dental implants. Smart release or on-demand activation surface coatings are a ``new piece of the puzzle{''}, which may be the most effective alternative for reducing microbial colonization on Ti surfaces, and future studies should focus on these technologies. (AU)

• Processo FAPESP: 20/05231-4 - Desenvolvimento de um novo hidrogel termosensitivo para liberação controlada de drogas direcionado a prevenção e ao tratamento de inflamações peri-implantares
• Beneficiário: Valentim Adelino Ricardo Barão
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 20/10436-4 - Síntese, caracterização e desempenho biológico de nanopolímeros pH-sensitivos produzidos por impressão molecular para o tratamento das infecções peri-implantares
• Beneficiário: Raphael Cavalcante Costa
• Modalidade de apoio: Bolsas no Brasil - Doutorado