Artepillin C Reduces Allergic Airway Inflammation by Induction of Monocytic Myeloid-Derived Suppressor Cells

Autor(es)

Martins, Nubia Sabrina ^[1] ; de Campos Fraga-Silva, Thais Fernanda ^[2] ; Correa, Giseli Furlan ^[2] ; Boko, Medeton Mahoussi Michael ^[1] ; Ramalho, Leandra Naira Zambelli ^[3] ; Rodrigues, Debora Munhoz ; Hori, Juliana Issa ^[4] ; Costa, Diego Luis ^{[2, 1]} ; Bastos, Jairo Kenupp ^[5] ; Bonato, Vania Luiza Deperon ^{[2, 1]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Basic & Appl Immunol Program, BR-14049900 Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Biochem & Immunol, BR-14049900 Ribeirao Preto, SP - Brazil

^[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Pathol & Legal Med, BR-14049900 Ribeirao Preto, SP - Brazil

^[4] Apis Flora Ind & Comercial Ltda, BR-14020670 Ribeirao Preto, SP - Brazil

^[5] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Pharmaceut Sci, BR-14049900 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PHARMACEUTICS; v. 13, n. 11 NOV 2021.
• Citações Web of Science: 0

Resumo

Propolis is a natural product produced by bees that is primarily used in complementary and alternative medicine and has anti-inflammatory, antibacterial, antiviral, and antitumoral biological properties. Some studies have reported the beneficial effects of propolis in models of allergic asthma. In a previous study, our group showed that green propolis treatment reduced airway inflammation and mucus secretion in an ovalbumin (OVA)-induced asthma model and resulted in increased regulatory T cells (Treg) and polymorphonuclear myeloid-derived suppressor cells (PMN-MDSC) frequencies in the lungs, two leukocyte populations that have immunosuppressive functions. In this study, we evaluated the anti-inflammatory effects of artepillin C (ArtC), the major compound of green propolis, in the context of allergic airway inflammation. Our results show that ArtC induces in vitro differentiation of Treg cells and monocytic MDSC (M-MDSC). Furthermore, in an OVA-induced asthma model, ArtC treatment reduced pulmonary inflammation, eosinophil influx to the airways, mucus and IL-5 secretion along with increased frequency of M-MDSC, but not Treg cells, in the lungs. Using an adoptive transfer model, we confirmed that the effect of ArtC in the reduction in airway inflammation was dependent on M-MDSC. Altogether, our data show that ArtC exhibits an anti-inflammatory effect and might be an adjuvant therapy for allergic asthma. (AU)

• Processo FAPESP: 19/09881-6 - Papel da sinalização dependente de TLR2 e TLR9 nas células epiteliais ou dendríticas na inflamação pulmonar durante a reexposição ao alérgeno e a infecção com pneumococo
• Beneficiário: Thais Fernanda de Campos Fraga da Silva
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 19/23446-0 - Avaliação do papel da quemerina na ativação da resposta inflamatória de macrófagos infectados com Mycobacterium tuberculosis
• Beneficiário: Giseli Furlan Corrêa
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 19/18793-3 - Potencial terapêutico do Artepelin C na asma alérgica experimental
• Beneficiário: Núbia Sabrina Martins
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 17/04138-8 - Realização de estudos químicos, analíticos, biológicos, farmacológicos e tecnológicos para preenchimento das lacunas no desenvolvimento do setor de própolis brasileiro
• Beneficiário: Jairo Kenupp Bastos
• Modalidade de apoio: Auxílio à Pesquisa - Temático