| Texto completo | |
| Autor(es): |
Lima, Rodrigo Vieira Costa
[1]
;
Stefano, Jose Tadeu
[1]
;
Malta, Fernanda de Mello
[1]
;
Pinho, Joao Renato Rebello
[1]
;
Carrilho, Flair Jose
[1]
;
Arrese, Marco
[2, 3]
;
Oliveira, Claudia P.
[1]
Número total de Autores: 7
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Lab Gastroenterol Clin & Expt LIM 07, Div Clin Gastroenterol & Hepat, Dept Gastroenterol, Hosp Clin HCFMUSP, Fac Med, BR-05403000 Sao Paulo, SP - Brazil
[2] Pontificia Univ Catolica Chile, Escuela Med, Dept Gastroenterol, Santiago 8330024 - Chile
[3] Pontificia Univ Catolica Chile, Fac Ciencias Biol, Dept Biol Celular & Mol, Ctr Envejecimiento & Regenerac CARE, Santiago 8330024 - Chile
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | BIOMEDICINES; v. 9, n. 12 DEC 2021. |
| Citações Web of Science: | 0 |
| Resumo | |
Liver biopsy is the gold standard for assessing fibrosis, but there is a need to seek non-invasive biomarkers for this purpose. The aim of this study was to evaluate the correlation between the serum levels of the microRNAs miR-21, miR-29a, miR-122, miR-155 and miR-181a and the phenotypic expression of NAFLD. A cross-sectional study was carried out on 108 NAFLD patients diagnosed by liver biopsy. FIB-4 and NAFLD fibrosis scores were calculated. The comparison between the distributions of microRNA values according to the presence or absence of histological fibrosis (F2-F4) was performed. A multivariate logistic regression analysis was performed to build a score for predicting fibrosis using FIB-4 and Ln (miR-181a) as independent variables. Only miR-181a showed a statistical difference between patients with significant liver fibrosis (>F2) and those without (F0-F1) (p = 0.017). FIB-4 revealed an AUC on the ROC curve of 0.667 to predict clinically significant fibrosis (F2-F4). When assessed using the score in association with Ln (miR-181a), there was an improvement in the ROC curve, with an AUC of 0.71. miR-181a can be used as a non-invasive method of predicting fibrosis in NAFLD, and an association with FIB-4 has the potential to increase the accuracy of each method alone. (AU) | |
| Processo FAPESP: | 18/03698-2 - PAPEL DOS MICRO-RNAs NA EXPRESSÃO FENOTÍPICA DA DOENÇA HEPÁTICA GORDUROSA NÃO ALCOÓLICA: DA ESTEATOSE AO CARCINOMA HEPATOCELULAR |
| Beneficiário: | Claudia Pinto Marques Souza de Oliveira |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |