Respiratory disorders of Parkinson's disease

Autor(es)

Aquino, Yasmin C. ^[1] ; Cabral, Lais M. ^[1] ; Miranda, Nicole C. ^[1] ; Naccarato, Monique C. ^[1] ; Falquetto, Barbara ^[1] ; Moreira, Thiago S. ^[2] ; Takakura, Ana C. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Ciencias Biomed, Dept Pharmacol, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Inst Ciencias Biomed, Dept Physiol & Biophys, Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Journal of Neurophysiology; v. 127, n. 1, p. 1-15, JAN 2022.
• Citações Web of Science: 0

Resumo

Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra, mainly affecting people over 60 yr of age. Patients develop both classic symptoms (tremors, muscle rigidity, bradykinesia, and postural instability) and nonclassical symptoms (orthostatic hypotension, neuropsychiatric deficiency, sleep disturbances, and respiratory disorders). Thus, patients with PD can have a significantly impaired quality of life, especially when they do not have multimodality therapeutic follow-up. The respiratory alterations associated with this syndrome are the main cause of mortality in PD. They can be classified as peripheral when caused by disorders of the upper airways or muscles involved in breathing and as central when triggered by functional deficits of important neurons located in the brainstem involved in respiratory control. Currently, there is little research describing these disorders, and therefore, there is no well-established knowledge about the subject, making the treatment of patients with respiratory symptoms difficult. In this review, the history of the pathology and data about the respiratory changes in PD obtained thus far will be addressed. (AU)

• Processo FAPESP: 15/23376-1 - Núcleo retrotrapezóide, quimiossensibilidade central e automaticidade respiratória
• Beneficiário: Thiago dos Santos Moreira
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 20/16320-8 - Investigação da existência de projeções anatômicas da substância negra para o complexo pré-Bötzinger
• Beneficiário: Yasmin Cestari Aquino
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 19/00065-1 - Participação do estresse oxidativo na degeneração dos neurônios respiratórios do bulbo no modelo animal de Doença de Parkinson
• Beneficiário: Bárbara Falquetto
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 19/01236-4 - Efeitos de tratamentos farmacológicos e não farmacológicos nas alterações respiratórias observadas em um modelo murino da Doença de Parkinson
• Beneficiário: Ana Carolina Takakura Moreira
• Modalidade de apoio: Auxílio à Pesquisa - Regular