eeping the host alive - lessons from obligate intracellular bacterial pathogen

Autor(es)

Loterio, Robson Kriiger ^{[1, 2]} ; Zamboni, Dario S. ^[1] ; Newton, Hayley J. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med Ribeirao Preto, Ribeirao Preto Med Sch, Dept Biol Celular & Mol & Bioagentes Patogen, FMRP, Av Bandeirantes 3900, BR-14049900 Ribeirao Preto, SP - Brazil

^[2] Univ Melbourne, Dept Microbiol & Immunol, Peter Doherty Inst Infect & Immun, 792 Elizabeth St, Melbourne, Vic 3000 - Australia

• Tipo de documento: Artigo de Revisão
• Fonte: PATHOGENS AND DISEASE; v. 79, n. 9 DEC 2021.
• Citações Web of Science: 1

Resumo

Mammals have evolved sophisticated host cell death signaling pathways as an important immune mechanism to recognize and eliminate cell intruders before they establish their replicative niche. However, intracellular bacterial pathogens that have co-evolved with their host have developed a multitude of tactics to counteract this defense strategy to facilitate their survival and replication. This requires manipulation of pro-death and pro-survival host signaling pathways during infection. Obligate intracellular bacterial pathogens are organisms that absolutely require an eukaryotic host to survive and replicate, and therefore they have developed virulence factors to prevent diverse forms of host cell death and conserve their replicative niche. This review encapsulates our current understanding of these host-pathogen interactions by exploring the most relevant findings of Anaplasma spp., Chlamydia spp., Rickettsia spp. and Coxiella burnetii modulating host cell death pathways. A detailed comprehension of the molecular mechanisms through which these obligate intracellular pathogens manipulate regulated host cell death will not only increase the current understanding of these difficult-to-study pathogens but also provide insights into new tools to study regulated cell death and the development of new therapeutic approaches to control infection. (AU)

• Processo FAPESP: 16/24275-7 - Identificação de proteínas de Coxiella burnetii envolvidas na modulação da ativação do inflamassoma e em vias de sinalização intracelular em macrófagos
• Beneficiário: Robson Kriiger Loterio
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 14/04684-4 - O inflamassoma na resposta contra patógenos intracelulares e os mecanismos microbianos relacionados à evasão
• Beneficiário: Dario Simões Zamboni
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 19/11342-6 - Mecanismos e consequências da ativação de receptores citoplasmáticos por patógenos intracelulares.
• Beneficiário: Dario Simões Zamboni
• Modalidade de apoio: Auxílio à Pesquisa - Temático