emale Prostate Development: Morphological Analysis of the Budding Dynami

Autor(es)

dos Santos, Fernanda C. A. ^[1] ; Negre, Ana F. P. ^[1] ; Rodriguez, Daniel A. O. ^[2] ; de Sousa, Gessica C. ^[1] ; Rodrigues, Giovanna A. ^[1] ; Sanches, Bruno D. A. ^[2] ; Carvalho, Hernandes F. ^[2] ; Taboga, Sebastiao R. ^[3] ; Biancardi, Manoel F. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Goias, Dept Histol Embryol & Cell Biol, Campus Samambaia, BR-74690900 Goiania, Go - Brazil

^[2] Univ Estadual Campinas, Dept Struct & Funct Biol, BR-13083862 Campinas, SP - Brazil

^[3] State Univ Sao Paulo, Dept Biol, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Microscopy and Microanalysis; v. 28, n. 1, p. 272-280, FEB 2022.
• Citações Web of Science: 0

Resumo

The presence of the prostate in female mammals has long been known. However, pieces of information related to its development are still lacking. The aim of this study was to explore the budding dynamic during the initial prostate development in female gerbils. Pregnant females were timed, the fetuses were euthanized, and the urogenital sinus was dissected out between the embryonic days 20 and 24 (E20-E24 groups). Newborn pups (1-day-old; P1 group) underwent the same procedures. The female prostate development was based on epithelial buds which arose far from the paraurethral mesenchyme (PAM). The epithelial buds reached the PAM at prenatal day 24, crossing a small gap in the smooth muscle layer between the periurethral mesenchyme (PEM) and the PAM. Steroid nuclear receptors such as the androgen receptor and estrogen receptor alpha were localized in the PEM through the urethral wall, although some epithelial labeling was also present in the urogenital sinus epithelium (UGE). P63-positive cells were found only in the UGE, becoming restricted to the basal compartment after the 23rd prenatal day. The results showed that the gerbil female prostate exhibits a distinct budding pattern as compared to the male prostate development. (AU)

• Processo FAPESP: 09/53990-2 - EMU: aquisição de microscópio de varredura confocal a laser para um centro multiusuário de microscopia da UNESP
• Beneficiário: Sebastião Roberto Taboga
• Modalidade de apoio: Auxílio à Pesquisa - Programa Equipamentos Multiusuários
• Processo FAPESP: 11/06335-9 - Efeitos da exposição intra-uterina e puberal a desreguladores endócrinos sobre a próstata de Gerbilos senis
• Beneficiário: Sebastião Roberto Taboga
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 11/20358-1 - Organogênese do lobo ventral da próstata do gerbilo da Mongólia (Meriones unguiculatus) durante o período pré-natal
• Beneficiário: Bruno Domingos Azevedo Sanches
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 09/16789-7 - Efeitos da exposição intra-uterina e puberal do cipionato de testosterona sobre a próstata de machos e fêmeas de gerbilos senis
• Beneficiário: Manoel Francisco Biancardi
• Modalidade de apoio: Bolsas no Brasil - Doutorado