Hippo pathway-related genes expression is deregulated in myeloproliferative neoplasms

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Cacemiro, Maira da Costa ; Cominal, Jucara Gastaldi ; Pereira, Luiz Miguel ; Berzoti-Coelho, Maria Gabriela ; Berbel, Giovana Michelassi ; Baroni, Luciana ; Malta, Tathiane ; Tognon, Raquel ; Nunes, Natalia de Souza ; Souto, Elizabeth Xisto ; De Figueiredo-Pontes, Lorena Lobo ; Yatsuda, Ana Patricia ; de Castro, Fabiola Attie

• Tipo de documento: Artigo Científico
• Fonte: MEDICAL ONCOLOGY; v. 39, n. 5, p. 11-pg., 2022-05-01.

Resumo

Myeloproliferative neoplasms (MPN) are hematological disorders characterized by increased proliferation of precursor and mature myeloid cells. MPN patients may present driver mutations in JAK2, MPL, and CALR genes, which are essential to describe the molecular mechanisms of MPN pathogenesis. Despite all the new knowledge on MPN pathogenesis, many questions remain to be answered to develop effective therapies to cure MPN or impair its progression to acute myeloid leukemia. The present study examined the expression levels of the Hippo signaling pathway members in patients with polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF), as well as the role that they play in disease pathogenesis. The Hippo pathway is a tumor suppressor pathway that participates in the regulation of cell proliferation, differentiation, and death. Our main finding was that the expression of tumor suppressor genes from Hippo pathway were downregulated and seemed to be associated with cell resistance to apoptosis and increased proliferation rate. Therefore, the decreased expression of Hippo pathway-related genes may contribute to the malignant phenotype, apoptosis resistance, and cell proliferation in MPN pathogenesis. (AU)

• Processo FAPESP: 13/08135-2 - CTC - Centro de Terapia Celular
• Beneficiário: Dimas Tadeu Covas
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 14/50947-7 - INCT 2014: em Células Tronco e Terapia Celular no Câncer
• Beneficiário: Dimas Tadeu Covas
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 15/23555-3 - MicroRNAs reguladores da via HIPPO em Leucemia Mielóide Crônica
• Beneficiário: Maria Gabriela Berzoti Coelho
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 18/19714-7 - Influência das alterações das células estromais mesenquimais multipotentes da medula óssea na fisiopatologia e progressão das neoplasias mieloproliferativas BCR-ABL1-
• Beneficiário: Fabíola Attié de Castro
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 15/21866-1 - Regulação da célula-tronco hematopoética normal e neoplásica mediada por citocinas secretadas pelas células natural killer
• Beneficiário: Lorena Lôbo de Figueiredo Pontes
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 14/04234-9 - Expressão das moléculas da via HIPPO/LATS em neoplasias mieloproliferativas crônicas
• Beneficiário: Maira da Costa Cacemiro
• Modalidade de apoio: Bolsas no Brasil - Doutorado