Temporomandibular disorder in construction workers associated with ANKK1 and DRD2 genes

Autor(es)

Samantha Schaffer Pugsley Baratto ^[1] ; Michelle Nascimento Meger ^[2] ; Vânia Camargo ^[3] ; Gisele Maria Correr Nolasco ^[4] ; Natanael Henrique Ribeiro Mattos ^[5] ; Liliane Roskamp ^[6] ; José Stechman-Neto ^[7] ; Isabela Ribeiro Madalena ; Erika Calvano Küchler ; Flares Baratto-Filho

Afiliação do(s) autor(es)

^[1] UniDomBosco University Center. School of Dentistry - Brasil

^[2] University of Tuiuti of Paraná. School of Dentistry - Brasil

^[3] Positivo University. School of Health Sciences - Brasil

^[4] University of Tuiuti of Paraná. School of Dentistry - Brasil

^[5] University of Tuiuti of Paraná. School of Dentistry - Brasil

^[6] University of Tuiuti of Paraná. School of Dentistry - Brasil

^[7] University of Tuiuti of Paraná. School of Dentistry - Brasil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Dental Journal; v. 33, n. 4, p. 12-20, 2022-08-26.

Resumo

Abstract The study aimed to explore the influence of genetic polymorphisms in ANKK1 and DRD2 on the signs and symptoms of temporomandibular disorder (TMD) in construction workers. This cross-sectional study included only male subjects. All construction workers were healthy and over 18 years age. Illiterate workers and functionally illiterate workers were excluded. The diagnosis of TMD was established according to the Research Diagnostic Criteria for TMD (RDC/TMD). Genomic DNA was used to evaluate the genetic polymorphisms ANKK1 (rs1800497) and DRD2 (rs6275; rs6276) using Real-Time PCR. Chi-square or Fisher exact tests were used to evaluate genotypes and allele distribution among the studied phenotypes. The established alpha of this study was 5%. The sample included a total of 115 patients. The age of the patients ranged from 19 to 70 years (mean age 38.2; standard deviation 11.7). Chronic pain (87.7%), disc displacement (38.2%), and joint inflammation (26.9%) were the most frequently observed signs and symptoms. The genetic polymorphism rs6276 in DRD2 was associated with chronic pain (p=0.033). In conclusion, our study suggests that genetic polymorphisms in DRD2 and ANKK1 may influence TMD signs and symptoms in a group of male construction workers. (AU)

• Processo FAPESP: 15/06866-5 - Avaliação do papel do estrógeno no desenvolvimento dentofacial
• Beneficiário: Erika Calvano Kuchler
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 16/08149-1 - Avaliação do papel do estrógeno nos tecidos dentofaciais
• Beneficiário: Erika Calvano Kuchler
• Modalidade de apoio: Bolsas no Brasil - Jovens Pesquisadores