Dynamics of SARS-CoV-2 Variants of Concern in Vaccination Model City in the State of Sao Paulo, Brazil

Autor(es):Mostrar menos -

Slavov, Svetoslav Nanev ; Lima de la-Roque, Debora Glenda ; Mendes da Costa, Pericles Natan ; Rodrigues, Evandra Strazza ; Santos, Elaine Vieira ; Borges, Josiane Serrano ; Evaristo, Mariane ; Maconetto, Juliana de Matos ; Marques, Adriana Aparecida ; Milhomens, Jonathan ; Ros, Felipe Augusto ; Fonseca, Vagner ; Jeronimo Lima, Alex Ranieri ; Ribeiro, Gabriela ; Oliveira de Lima, Loyze Paola ; Marques Garibaldi, Pedro Manuel ; Ferreira, Natasha Nicos ; Moraes, Glenda Renata ; Marqueze, Elaine Cristina ; dos Santos Barros, Claudia Renata ; Martins, Antonio Jorge ; Coutinho, Luiz Lehmann ; Calado, Rodrigo Tocantins ; Borges, Marcos ; Elias, Maria Carolina ; Sampaio, Sandra Coccuzzo ; Giovanetti, Marta ; Junior Alcantara, Luiz Carlos ; Covas, Dimas Tadeu ; Kashima, Simone

• Tipo de documento: Artigo Científico
• Fonte: Viruses-Basel; v. 14, n. 10, p. 12-pg., 2022-10-01.

Resumo

From a country with one of the highest SARS-CoV-2 morbidity and mortality rates, Brazil has implemented one of the most successful vaccination programs. Brazil's first model city vaccination program was performed by the CoronaVac vaccine (Sinovac Biotech) in the town of Serrana, Sao Paulo State. To evaluate the vaccination effect on the SARS-CoV-2 molecular dynamics and clinical outcomes, we performed SARS-CoV-2 molecular surveillance on 4375 complete genomes obtained between June 2020 and April 2022 in this location. This study included the period between the initial SARS-CoV-2 introduction and during the vaccination process. We observed that the SARS-CoV-2 substitution dynamics in Serrana followed the viral molecular epidemiology in Brazil, including the initial identification of the ancestral lineages (B.1.1.28 and B.1.1.33) and epidemic waves of variants of concern (VOC) including the Gamma, Delta, and, more recently, Omicron. Most probably, as a result of the immunization campaign, the mortality during the Gamma and Delta VOC was significantly reduced compared to the rest of Brazil, which was also related to lower morbidity. Our phylogenetic analysis revealed the evolutionary history of the SARS-CoV-2 in this location and showed that multiple introduction events have occurred over time. The evaluation of the COVID-19 clinical outcome revealed that most cases were mild (88.9%, 98.1%, 99.1% to Gamma, Delta, and Omicron, respectively) regardless of the infecting VOC. In conclusion, we observed that vaccination was responsible for reducing the death toll rate and related COVID-19 morbidity, especially during the gamma and Delta VOC; however, it does not prevent the rapid substitution rate and morbidity of the Omicron VOC. (AU)

• Processo FAPESP: 14/50947-7 - INCT 2014: em Células Tronco e Terapia Celular no Câncer
• Beneficiário: Dimas Tadeu Covas
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 18/15826-5 - Avaliação do impacto de vírus emergentes e re-emergentes em hemoterapia e transplante de células-tronco por meio de técnicas moleculares avançadas
• Beneficiário: Svetoslav Nanev Slavov
• Modalidade de apoio: Bolsas no Brasil - Jovens Pesquisadores
• Processo FAPESP: 20/10127-1 - Desenvolvimento de vacina contra a COVID-19
• Beneficiário: Dimas Tadeu Covas
• Modalidade de apoio: Auxílio à Pesquisa - Pesquisa em Políticas Públicas
• Processo FAPESP: 20/06441-2 - aplicação dos recursos da Reserva Técnica Institucional para melhoria das atividades de pesquisa do Instituto Butantan.
• Beneficiário: Sandra Coccuzzo Sampaio Vessoni
• Modalidade de apoio: Auxílio à Pesquisa - Reserva Técnica para Infraestrutura Institucional de Pesquisa
• Processo FAPESP: 19/22155-2 - Caracterização celular dos nichos hematopoéticos de modelo murino da anemia falciforme
• Beneficiário: Felipe Augusto Rós
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 17/26950-6 - Aloimunização eritrocitária na doença falciforme: identificação de variantes do sistema rh e de marcadores imunológicos
• Beneficiário: Evandra Strazza Rodrigues Sandoval
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 21/11944-6 - Contínuo aprimoramento de vacinas: Centro para Vigilância Viral e Avaliação Sorológica (CeVIVAS)
• Beneficiário: Sandra Coccuzzo Sampaio Vessoni
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Ciência para o Desenvolvimento
• Processo FAPESP: 13/08135-2 - CTC - Centro de Terapia Celular
• Beneficiário: Dimas Tadeu Covas
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs