Mucoadhesive Nanosystems for Nose-to-Brain Drug Delivery in the Treatment of Central Nervous System Diseases

Autor(es)

Di Filippo, Leonardo Delello ; Duarte, Jonatas ; Fonseca-Santos, Bruno ; Tavares Junior, Alberto Gomes ; Araujo, Victor ; Roque Borda, Cesar Augusto ; Vicente, Eduardo Festozo ; Chorilli, Marlus

• Tipo de documento: Artigo Científico
• Fonte: Current Medicinal Chemistry; v. 29, n. 17, p. 32-pg., 2022-01-01.

Resumo

The diseases affecting the Central Nervous System (CNS) can have varied etiopathology, but they have in common silent progression, global incidence, and significant impacts on the quality of life of patients and public health systems. With the advance of biomedicine and pharmaceutical technology, new and more modern diagnostic methods and treatments were developed, repurposing the use of drugs currently available for the treatment of CNS diseases. An attractive approach is the use of alternative drug delivery platforms, such as nanocarriers, and less invasive administration routes, such as the nose-to-brain, extensively explored for the delivery of drugs into the CNS. Despite many promising results, the nose-to-brain route has some physiological limitations that make it difficult to deliver drugs satisfactorily to exert therapeutic activity in the CNS. To overcome these limitations, nanostructured systems with mucoadhesive properties have stood out over the last few years in pharmaceutical R&D. In this review; we discuss how the nose-to-brain route limitations can influence the delivery of drugs to the CNS and highlight the benefits that mucoadhesion can bring to these nanostructured systems. The main findings in the literature are brought together and discussed critically, focusing on how mucoadhesion can improve the biopharmaceutical properties of molecules used in the clinic, as well as their biological performance. Finally, conclusions are drawn about the points of strength of mucoadhesive nanosystems and the points that still need attention to successfully use the nose-to-brain route for the treatment of diseases that affect the CNS. (AU)

• Processo FAPESP: 20/12622-0 - Avaliação do potencial de carreadores lipídicos nanoestruturados funcionalizados com cetuximabe dispersos em hidrogéis termo-responsivos mucoadesivos para administração intranasal de temozolomida no tratamento do Glioblastoma Multiforme
• Beneficiário: Leonardo Delello Di Filippo
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 19/25125-7 - Nanoemulsões contendo terpenos como potenciais larvicidas e repelentes contra Aedes aegypti (Linnaeus, 1762)
• Beneficiário: Jonatas Lobato Duarte
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 20/16573-3 - Estudos in vitro e in vivo de análogos do peptídeo antimicrobiano B1CTcu5 encapsulados em micropartículas colón-específicas frente ao Mycobacterium tuberculosis
• Beneficiário: Cesar Augusto Roque Borda
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 18/23416-1 - Nanoencapsulação de extratos de Arrabidae chica com potencial analgésico e anti-inflamatório para uso tópico
• Beneficiário: Bruno da Fonseca dos Santos
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado