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Ferroptosis Modulation: Potential Therapeutic Target for Glioblastoma Treatment

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Autor(es):
de Souza, Izadora ; Clares Ramalho, Maria Carolina ; Guedes, Camila Banca ; Araujo Osawa, Isabeli Yumi ; Seregni Monteiro, Linda Karolynne ; Gomes, Luciana Rodrigues ; Reily Rocha, Clarissa Ribeiro
Número total de Autores: 7
Tipo de documento: Artigo Científico
Fonte: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 23, n. 13, p. 21-pg., 2022-07-01.
Resumo

Glioblastoma multiforme is a lethal disease and represents the most common and severe type of glioma. Drug resistance and the evasion of cell death are the main characteristics of its malignancy, leading to a high percentage of disease recurrence and the patients' low survival rate. Exploiting the modulation of cell death mechanisms could be an important strategy to prevent tumor development and reverse the high mortality and morbidity rates in glioblastoma patients. Ferroptosis is a recently described type of cell death, which is characterized by iron accumulation, high levels of polyunsaturated fatty acid (PUFA)-containing phospholipids, and deficiency in lipid peroxidation repair. Several studies have demonstrated that ferroptosis has a potential role in cancer treatment and could be a promising approach for glioblastoma patients. Thus, here, we present an overview of the mechanisms of the iron-dependent cell death and summarize the current findings of ferroptosis modulation on glioblastoma including its non-canonical pathway. Moreover, we focused on new ferroptosis-inducing compounds for glioma treatment, and we highlight the key ferroptosis-related genes to glioma prognosis, which could be further explored. Thereby, understanding how to trigger ferroptosis in glioblastoma may provide promising pharmacological targets and indicate new therapeutic approaches to increase the survival of glioblastoma patients. (AU)

Processo FAPESP: 19/27080-0 - Papel da autofagia mediada por chaperona em câncer de mama
Beneficiário:Luciana Rodrigues Gomes
Modalidade de apoio: Auxílio à Pesquisa - Regular
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Beneficiário:Nadja Cristhina de Souza Pinto
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 19/19435-3 - Papel de danos no DNA e função mitocondrial em envelhecimento vascular, imune e neurológico (DNA MoVINg)
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Modalidade de apoio: Auxílio à Pesquisa - Temático
Processo FAPESP: 13/07467-1 - CeTICS - Centro de Toxinas, Imuno-Resposta e Sinalização Celular
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Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
Processo FAPESP: 19/26268-6 - Explorando o papel da ferroptose na indução de morte por temozolomida em glioblastoma
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Modalidade de apoio: Bolsas no Brasil - Mestrado
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Modalidade de apoio: Auxílio à Pesquisa - Regular