WNT5A in tumor development and progression: A comprehensive review

Autor(es)

Bueno, Maura Lima Pereira ; Saad, Sara Teresinha Olalla ; Roversi, Fernanda Marconi

• Tipo de documento: Artigo Científico
• Fonte: BIOMEDICINE & PHARMACOTHERAPY; v. 155, p. 18-pg., 2022-10-18.

Resumo

The investigation of tumor microenvironment (TME) is essential to better characterize the complex cellular crosstalk and to identify important immunological phenotypes and biomarkers. The niche is a crucial contributor to neoplasm initiation, maintenance and progression. Therefore, a deeper analysis of tumor surroundings could improve cancer diagnosis, prognosis and assertive treatment. Thus, the WNT family exerts a critical action in tumorigenesis of different types of neoplasms due to dysregulations in the TME. WNT5A, an evolutionary WNT member, is involved in several cellular and physiopathological processes, in addition to tissue homeostasis. The WNT5A protein exerts paradoxical effects while acting as both an oncogene or tumor suppressor by regulating several non-canonical signaling pathways, and consequently interfering in cell growth, cytoskeletal remodeling, migration and invasiveness. This review focuses on a thorough characterization of the role of WNT5A in neoplastic transformation and progression, which may help to understand the prognostic potentiality of WNT5A and its features as a therapeutic target in several cancers. Additionally, we herein summarized novel findings on the mechanisms by which WNT5A might favor tumorigenesis or suppression of cancer progression and discussed the recently developed treatment strategies using WNT5A as a protagonist. (AU)

• Processo FAPESP: 19/25247-5 - Estudo da atividadecitotóxica e antitumoral de fármacos inibidores de MAPK e WNT associados a substâncias naturais em modelos in vitro
• Beneficiário: Maura Lima Pereira Bueno
• Modalidade de apoio: Bolsas no Brasil - Programa Capacitação - Treinamento Técnico
• Processo FAPESP: 17/21801-2 - Preditores de gravidade e novos tratamentos para neoplasias da medula óssea
• Beneficiário: Sara Teresinha Olalla Saad
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 21/05320-0 - Perfil dos universitários brasileiros que fazem uso de cigarro eletrônico: um estudo epidemiológico sobre um consumo proibido
• Beneficiário: Gabriella dos Santos Maximino
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica