A systematic review and meta-analysis of the effect of thymol as an anti-inflammatory and wound healing agent A review of thymol effect on inflammation and wound healing

Autor(es)

Gabbai-Armelin, Paulo R. ; Sales, Luciana S. ; Ferrisse, Tulio Morandin ; De Oliveira, Analu Barros ; De Oliveira, Juliana R. ; Giro, Elisa M. A. ; Brighenti, Fernanda L.

• Tipo de documento: Artigo Científico
• Fonte: Phytotherapy Research; v. 36, n. 9, p. 29-pg., 2022-07-18.

Resumo

Thymol (THY) exhibits antibacterial and antioxidant properties. Recent studies have also shown that THY presents anti-inflammatory and healing properties. This review focused on in vitro and in vivo investigations related to THY utilization, as an anti-inflammatory and/or wound healing agent. PubMed, WebOfScience, and Scopus were examined. Independent reviewers conducted all diagram steps. PRISMA was followed for data extraction. RoB 2 and SYRCLE were utilized to assess the risk of bias for in vitro and animal studies. Meta-analysis was performed for in vitro and in vivo articles that investigated THY as an anti-inflammatory agent. Thirty-six and 15 articles were included in the qualitative analysis and meta-analysis, respectively. Studies showed high risk of bias related to sampling, allocation procedures, randomization, and blinding. Even so, for in vitro studies, significant result was observed for IL-2. For in vivo studies, significant results were found for IL-1, IL-17, TNF-alpha, AST, MPO, and CRP, with higher levels noticed in control groups. THY presents significant properties as anti-inflammatory, ameliorating affections of the digestive system, cardiovascular problems, respiratory system and dermal damages, and burns. Researches are needed to clarify THY dose-response relationship and its mechanism of action, especially in the application of THY as a healing agent. (AU)

• Processo FAPESP: 20/07110-0 - Potencial da terapia fotodinâmica na modulação da resposta inflamatória e nos fatores de virulência microbianos: avaliação em modelo de co-culturas tridimensionais de fibroblastos gengivais, Candida albicans e Staphylococcus aureus
• Beneficiário: Analú Barros de Oliveira
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 19/08375-0 - Potencialização do efeito anticárie e antibiofilme de substâncias convencionais: avaliação em modelo de biofilme polimicrobiano
• Beneficiário: Fernanda Lourenção Brighenti
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 21/01191-0 - Indução de tolerância e caracterização do biofime de Candida albicans submetido à terapia fotodinâmica antimicrobiana
• Beneficiário: Túlio Morandin Ferrisse
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 19/26066-4 - Sistemas multiparticulados mucoadesivos para liberação controlada de substâncias naturais
• Beneficiário: Luciana Solera Sales
• Modalidade de apoio: Bolsas no Brasil - Doutorado