Dysregulated autoantibodies targeting vaso- and immunoregulatory receptors in Post COVID Syndrome correlate with symptom severity

Autor(es):Mostrar menos -

Sotzny, Franziska ; Filgueiras, Igor Salerno ; Kedor, Claudia ; Freitag, Helma ; Wittke, Kirsten ; Bauer, Sandra ; Sepulveda, Nuno ; Mathias da Fonseca, Dennyson Leandro ; Baiocchi, Gabriela Crispim ; Marques, Alexandre H. C. ; Kim, Myungjin ; Lange, Tanja ; Placa, Desiree Rodrigues ; Luebber, Finn ; Paulus, Frieder M. ; De Vito, Roberta ; Jurisica, Igor ; Schulze-Forster, Kai ; Paul, Friedemann ; Bellmann-Strobl, Judith ; Rust, Rebekka ; Hoppmann, Uta ; Shoenfeld, Yehuda ; Riemekasten, Gabriela ; Heidecke, Harald ; Cabral-Marques, Otavio ; Scheibenbogen, Carmen

• Tipo de documento: Artigo Científico
• Fonte: FRONTIERS IN IMMUNOLOGY; v. 13, p. 17-pg., 2022-09-27.

Resumo

Most patients with Post COVID Syndrome (PCS) present with a plethora of symptoms without clear evidence of organ dysfunction. A subset of them fulfills diagnostic criteria of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Symptom severity of ME/CFS correlates with natural regulatory autoantibody (AAB) levels targeting several G-protein coupled receptors (GPCR). In this exploratory study, we analyzed serum AAB levels against vaso- and immunoregulatory receptors, mostly GPCRs, in 80 PCS patients following mild-to-moderate COVID-19, with 40 of them fulfilling diagnostic criteria of ME/CFS. Healthy seronegative (n=38) and asymptomatic post COVID-19 controls (n=40) were also included in the study as control groups. We found lower levels for various AABs in PCS compared to at least one control group, accompanied by alterations in the correlations among AABs. Classification using random forest indicated AABs targeting ADRB2, STAB1, and ADRA2A as the strongest classifiers (AABs stratifying patients according to disease outcomes) of post COVID-19 outcomes. Several AABs correlated with symptom severity in PCS groups. Remarkably, severity of fatigue and vasomotor symptoms were associated with ADRB2 AAB levels in PCS/ME/CFS patients. Our study identified dysregulation of AAB against various receptors involved in the autonomous nervous system (ANS), vaso-, and immunoregulation and their correlation with symptom severity, pointing to their role in the pathogenesis of PCS. (AU)

• Processo FAPESP: 20/16246-2 - Caracterização holística do mecanismo de exaustão dos linfócitos T em pacientes com Zika
• Beneficiário: Dennyson Leandro Mathias da Fonseca
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 20/01688-0 - Análise sistêmica e integrativa da resposta imune às infecções virais por Zika e Dengue
• Beneficiário: Otávio Cabral Marques
• Modalidade de apoio: Bolsas no Brasil - Jovens Pesquisadores
• Processo FAPESP: 20/07069-0 - Análise sistêmica e integrativa dos mecanismos de exaustão dos linfócitos T de pacientes com COVID-19
• Beneficiário: Otávio Cabral Marques
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 18/18886-9 - Análise sistêmica e integrativa da resposta imune às infecções virais por Zika e Dengue
• Beneficiário: Otávio Cabral Marques
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 20/11710-2 - Análise sistêmica e integrativa dos mecanismos de exaustão dos linfócitos T de pacientes com Dengue
• Beneficiário: Desirée Rodrigues Plaça
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 20/07972-1 - Análise sistêmica e integrativa dos mecanismos de exaustão dos linfócitos T de pacientes com COVID-19
• Beneficiário: Gabriela Crispim Baiocchi
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto