Exercise training and DNA methylation profile in post-bariatric women: Results from an exploratory study

Autor(es):Mostrar menos -

Nicoletti, Carolina F. ; Roschel, Hamilton ; Merege-Filho, Carlos ; Lima, Alisson P. ; Gil, Saulo ; Pinhel, Marcela A. S. ; Noronha, Natalia Y. ; Santo, Marco A. ; Jacome, Amalia ; Crujeiras, Ana B. ; Gualano, Bruno ; Nonino, Carla B.

• Tipo de documento: Artigo Científico
• Fonte: FRONTIERS IN SPORTS AND ACTIVE LIVING; v. 5, p. 5-pg., 2023-02-08.

Resumo

Exercise training and bariatric surgery have been shown to independently modulate DNA methylation profile in clusters of genes related to metabolic and inflammatory pathways. This study aimed to investigate the effects of a 6-month exercise training program on DNA methylation profile in women who underwent bariatric surgery. In this exploratory, quasi-experimental study, we analyzed DNA methylation levels by array technology in eleven women who underwent Roux-en-Y Gastric Bypass and a 6-month, three-times-a-week, supervised exercise training program. Epigenome Wide Association Analysis showed 722 CpG sites with different methylation level equal to or greater than 5% (P < 0.01) after exercise training. Some of these CpGs sites were related to pathophysiological mechanisms of inflammation, specially Th17 cell differentiation (FDR value < 0.05 and P < 0.001). Our data showed epigenetic modification in specific CpG sites related to Th17 cell differentiation pathway in post-bariatric women following a 6-months exercise training program. (AU)

• Processo FAPESP: 17/13552-2 - Reduzindo tempo sedentário em populações clínicas: o estudo take a stand for health
• Beneficiário: Bruno Gualano
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 16/05638-1 - Padrão de metilação global do DNA antes e após tratamentos para perda de peso
• Beneficiário: Carla Barbosa Nonino
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 15/18669-0 - Avaliação do padrão de metilação do DNA antes e após derivação gástrica em Y-de-Roux
• Beneficiário: Carolina Nicoletti Ferreira Fino
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado