Limitations and advances in new treatments and future perspectives of corneal blindness

Autor(es)

Antunes-Foschini, Rosalia ; Adriano, Leidiane ; Batista Murashima, Adriana de Andrade ; Barbosa, Amanda Pires ; Nominato, Luis Fernando ; Dias, Lara Cristina ; Fantucci, Marina Zilio ; Garcia, Denny Marcos ; Alves, Monica ; Rocha, Eduardo Melani

• Tipo de documento: Artigo Científico
• Fonte: Arquivos Brasileiros de Oftalmologia; v. 84, n. 3, p. 15-pg., 2021-05-01.

Resumo

This review is intended to describe the therapeutic approaches for corneal blindness, detailing the steps and elements involved in corneal wound healing. It also presents the limitations of the actual surgical and pharmacological strategies used to restore and maintain corneal transparency in terms of long-term survival and geographic coverage. In addition, we critically review the perspectives of anabolic agents, including vitamin A, hormones, growth factors, and novel promitotic and anti-inflammatory modulators, to assist corneal wound healing. We discuss the studies involving nanotechnology, gene therapy, and tissue reengineering as potential future strategies to work solely or in combination with corneal surgery to prevent or revert corneal blindness. (AU)

• Processo FAPESP: 14/22451-7 - Sistemas de liberação sustentada e direcionada de fármacos para o tecido epitelial
• Beneficiário: Renata Fonseca Vianna Lopez
• Modalidade de apoio: Auxílio à Pesquisa - Temático