Co-production of Classes A and B Carbapenemases BK... - BV FAPESP
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Co-production of Classes A and B Carbapenemases BKC-1 and VIM-2 in a Clinical Pseudomonas Putida Group Isolate from Brazil

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Autor(es):
Yamada, Amanda Yaeko ; de Souza, Andreia Rodrigues ; de Castro Lima, Marisa de Jesus ; Reis, Alex Domingos ; Campos, Karoline Rodrigues ; de Jesus Bertani, Amanda Maria ; Tadeu de Araujo, Leonardo Jose ; Sacchi, Claudio Tavares ; Tiba-Casas, Monique Ribeiro ; Camargo, Carlos Henrique
Número total de Autores: 10
Tipo de documento: Artigo Científico
Fonte: Current Microbiology; v. 79, n. 9, p. 5-pg., 2022-09-01.
Resumo

Emergence of resistance to classical antimicrobial agents is a public health issue, especially in countries with high antimicrobial consumption rates. Carbapenems have been employed as first-choice option for empirical treatment complicated infections. However, in the last decades, frequency of carbapenemase-producing Gram-negative bacteria has rising, demanding the use of alternative antimicrobial agents. By sequencing the entire genomes with short and long reads technologies, we report the isolation and genomic characterization of a carbapenem-resistant Pseudomonas clinical isolate. The identification based on average nucleotide identity indicates a putative new species into the Pseudomonas putida Group, which carries both the bla(BKC-1) and bla(VIM-2) carbapenemase genes. The bla(BKC-1) was found to be on a transferable IncQ plasmid backbone, whereas bla(VIM-2) was found in a new integron, In2126 (intl1 increment -bla(VIM-2)-aacA7-bla(VIM-2) increment -aacA27-3'CS), described in this study. Our findings indicate that co-occurrence of classes A and B carbapenemase enzymes underscores the evolving emergence of more complex antimicrobial resistance in opportunistic pathogens. (AU)

Processo FAPESP: 17/50333-7 - Plano de desenvolvimento institucional em pesquisa do Instituto Adolfo Lutz (PDIp)
Beneficiário:Carlos Henrique Camargo
Modalidade de apoio: Auxílio à Pesquisa - Programa Modernização de Institutos Estaduais de Pesquisa
Processo FAPESP: 18/21193-5 - EMU concedido no processo 2017/50333-7: sequenciador genético de DNA
Beneficiário:Carlos Henrique Camargo
Modalidade de apoio: Auxílio à Pesquisa - Programa Equipamentos Multiusuários
Processo FAPESP: 18/21192-9 - EMU concedido no processo 2017/50333-7: MALDI-TOF
Beneficiário:Carlos Henrique Camargo
Modalidade de apoio: Auxílio à Pesquisa - Programa Equipamentos Multiusuários