Placental model as an important tool to study maternal-fetal interface

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Goncalves, Bianca M. ; Graceli, Jones B. ; da Rocha, Paula B. ; Tilli, Helena P. ; Vieira, Ester M. ; de Sibio, Maria T. ; Peghinelli, Vinicius V. ; Depra, Igor C. ; Mathias, Lucas S. ; Olimpio, Regiane M. C. ; Belik, Virginia C. ; Nogueira, Celia R.

• Tipo de documento: Artigo Científico
• Fonte: REPRODUCTIVE TOXICOLOGY; v. 112, p. 7-pg., 2022-09-01.

Resumo

The placenta is a temporary organ that plays critical roles at the maternal-fetal interface. Normal development and function of the placenta is dependent on hormonal signaling pathways that make the placenta a target of endocrine disrupting chemical (EDC) action. Studies showing association between prenatal exposure, hormone disruption, and reproductive damage indicate that EDCs are developmentally toxic and can impact future gen-erations. In this context, new placental models (trophoblast-derived cell lines, organotypic or 3D cell models, and physiologically based kinetic models) have been developed in order to create new approach methodology (NAM) to assess and even prevent such disastrous toxic harm in future generations. With the widespread discouragement of conducting animal studies, it has become irrefutable to develop in vitro models that can serve as a substitute for in vivo models. The goal of this review is to discuss the newest in vitro models to understand the maternal -fetal interface and predict placental development, physiology, and dysfunction generated by failures in molecular hormone control mechanisms, which, consequently, may change epigenetic programming to increase suscepti-bility to metabolic and other disorders in the offspring. We summarize the latest placental models for devel-opmental toxicology studies, focusing mainly on three-dimensional (3D) culture models. (AU)

• Processo FAPESP: 18/06178-0 - Rastreamento dos mecanismos controladores do imprint genômico placentário do locus DLK1-DIO3 em mulheres portadoras de hipotireoidismo: envolvimento do T3 na susceptibilidade ao DM2 na prole
• Beneficiário: Celia Regina Nogueira
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 19/09492-0 - Identificação de mecanismos moleculares envolvidos na possível relação entre Hipotireoidismo Gestacional e susceptibilidade ao Diabetes Mellitus tipo 2 por meio da construção de um modelo de barreira placentária humana em 3D
• Beneficiário: Bianca Mariani Gonçalves Meneghim
• Modalidade de apoio: Bolsas no Brasil - Doutorado