Increased Prevalence of Depression and Anxiety Among Subjects With Metabolic Syndrome in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

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Berto, Laura F. ; Suemoto, Claudia K. ; Moreno, Arlinda B. ; Fonseca, Maria de Jesus M. ; Nunes, Maria Angelica A. ; Molina, Maria del Carmen B. ; Barreto, Sandhi M. ; Diniz, Maria de Fatima Haueisen Sander ; Lotufo, Paulo A. ; Bensenor, Isabela M. ; Brunoni, Andre R.

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF THE ACADEMY OF CONSULTATION-LIAISON PSYCHIATRY; v. 63, n. 6, p. 10-pg., 2022-12-14.

Resumo

Background: Metabolic syndrome (MetS) and common mental disorders are prevalent conditions. However, the relationship of MetS and its components with depression, anxiety, and common mental disorders has not been suf-ficiently addressed in low-/middle-income countries. Objective: To investigate whether depression, anxiety, and common mental disorders are associated with MetS and its components in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Methods: A cross-sectional analysis of the ELSA-Brasil baseline visit (2008-2010) was performed. Adults without cardiovascular diseases had their MetS status defined by the National Cholesterol Ed-ucation Program's Adult Treatment Panel III criteria. We assessed mental disorders using the Clinical Interview Schedule-Revised. We employed multiple logistic regres-sion models adjusted for sociodemographic and behavioral factors. The dependent variables were mental disorders, and the independent variables were MetS and its components. We also performed analyses stratified by age and gender. Results: Our sample included 12,725 participants (54.9% women, mean age of 51.8 +/- 8.9 y). MetS and depressive disorders were significantly associated (odds ratio [OR] = 1.55, 95% confidence interval [CI] 1.30-1.85). Increased abdominal circumference (OR = 1.54, 95% CI 1.29-1.84), diabetes mellitus (OR = 1.24, 95% CI 1.02-1.50), hypertriglyceridemia (OR = 1.33, 95% CI 1.11-1.60), and low high-density lipoprotein cholesterol (only when adjusted for sociodemographic factors) (OR = 1.25, 95% CI 1.02-1.52) were also associated with depression. This association remained significant for all stratified analyses. Finally, MetS was also significantly associated with anxiety disorders (OR = 1.19, 95% CI 1.07-1.32) and common mental disorders (OR = 1.27, 95% CI 1.17-1.39). Conclusions: Our cross-sectional findings suggested that depression, anxiety, and common mental disorder are associated with MetS. Depression was also associated with abdominal obesity, elevated blood glucose, elevated triglycerides, and reduced high-density lipoprotein cholesterol, but not with hypertension. (Journal of the Academy of Consultation-Liaison Psy-chiatry 2022; 63:529-538) (AU)

• Processo FAPESP: 20/06887-0 - Associação entre a prevalência de Transtornos depressivos e ansiosos e Síndrome metabólica: uma análise transversal no ELSA- Brasil (Estudo Longitudinal de Saúde do Adulto)
• Beneficiário: Laura Fernandes Berto
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
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• Beneficiário: Andre Russowsky Brunoni
• Modalidade de apoio: Auxílio à Pesquisa - Temático
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• Beneficiário: Andre Russowsky Brunoni
• Modalidade de apoio: Auxílio à Pesquisa - Regular