The Effects of Transcranial Direct Current Stimulation in Obsessive-Compulsive Disorder Symptoms: A Meta-Analysis and Integrated Electric Fields Modeling Analysis

Autor(es)

Pinto, Bianca Silva ; Cavendish, Beatriz Araujo ; da Silva, Pedro Henrique Rodrigues ; Suen, Paulo Jeng Chian ; Marinho, Kalian Almeida Pereira ; Valiengo, Leandro da Costa Lane ; Vanderhasselt, Marie-Anne ; Brunoni, Andre Russowsky ; Razza, Lais Boralli

• Tipo de documento: Artigo Científico
• Fonte: BIOMEDICINES; v. 11, n. 1, p. 15-pg., 2023-01-01.

Resumo

Transcranial direct current stimulation (tDCS) has been showing promising effects for the treatment of obsessive-compulsive disorder (OCD), but there is still no conclusion on its efficacy for this disorder. We performed a systematic review and meta-analysis of trials using tDCS for OCD and a computer modeling analysis to evaluate the electric field (EF) strengths of different electrode assemblies in brain regions of interest (ROIs) (PROSPERO-42021262465). PubMed/MEDLINE, Embase, Cochrane Library and Web of Science databases were searched from inception to 25 September 2022. Randomized controlled trials (RCTs) and open-label studies were included. The primary aim was the effect size (Hedges' g) of continuous outcomes and potential moderators of response. For EF modeling, SimNIBS software was used. Four RCTs and four open-label trials were included (n = 241). Results revealed a large effect of tDCS in the endpoint, but no significant effect between active and sham protocols. No predictor of response was found. EF analysis revealed that montages using the main electrode over the (pre)supplementary motor area with an extracephalic reference electrode might lead to stronger EFs in the predefined ROIs. Our results revealed that tDCS might be a promising intervention to treat OCD; however, larger studies are warranted. (AU)

• Processo FAPESP: 21/10827-6 - Avaliação do volume do córtex pré-frontal dorsolateral esquerdo como preditor de resposta clínica ao uso da estimulação theta-burst no tratamento da depressão unipolar
• Beneficiário: Beatriz Araújo Cavendish
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 22/01197-1 - Terapias de Neuromodulação não-implantáveis: uma perspectiva para o cérebro deprimido
• Beneficiário: Bianca Silva Pinto
• Modalidade de apoio: Bolsas no Brasil - Programa Capacitação - Treinamento Técnico