Muscle endoplasmic reticulum stress in exercise

Autor(es)

Marafon, Bruno B. ; Pinto, Ana P. ; Ropelle, Eduardo R. ; de Moura, Leandro P. ; Cintra, Dennys E. ; Pauli, Jose R. ; da Silva, Adelino S. R.

• Tipo de documento: Artigo Científico
• Fonte: ACTA PHYSIOLOGICA; v. 235, n. 1, p. 13-pg., 2022-02-21.

Resumo

The endoplasmic reticulum (ER) is an organelle responsible for the post-translational folding and modification of proteins. Under stress conditions, such as physical exercise, there is accumulation of misfolded proteins. The increased load of proteins in the ER results in ER stress, which activates the unfolded protein response (UPR). UPR is comprised of three parallel pathways, responsible for ensuring the quality of secreted proteins. Scientific studies show that resistance or endurance acute physical exercise can induce ER stress and activate the UPR pathways. On the other hand, regular moderate-intensity exercise can attenuate the responses of genes and proteins related to ER stress. However, these positive adaptations do not occur when exercise intensity and volume increase without adequate rest periods, which is observed in overtraining. The current review discusses the frontier-of-knowledge findings on the effects of different acute and chronic physical exercise protocols on skeletal muscle ER stress and its metabolic consequences. (AU)

• Processo FAPESP: 21/08693-1 - Efeito da deleção global ou condicional (músculo esquelético) do gene Nr1d1 sobre o envelhecimento
• Beneficiário: Ana Paula Pinto
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 20/04269-8 - Papel do TLR4 no estresse do retículo endoplasmático induzido pelo exercício físico no músculo esquelético
• Beneficiário: Bruno Brieda Marafon
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 19/11820-5 - Função do Nr1d1 sobre a Sarcopenia associada ao envelhecimento
• Beneficiário: Adelino Sanchez Ramos da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Temático