Busca avançada
Ano de início
Entree


Population-based genomic study of Plasmodium vivax malaria in seven Brazilian states and across South America

Texto completo
Autor(es):
Mostrar menos -
Ibrahim, Amy ; Manko, Emilia ; Dombrowski, Jamille G. ; Campos, Monica ; Benavente, Ernest Diez ; Nolder, Debbie ; Sutherland, Colin J. ; Nosten, Francois ; Fernandez, Diana ; Velez-Tobon, Gabriel ; Castano, Alberto Tobon ; Aguiar, Anna Caroline C. ; Pereira, Dhelio Batista ; Santos, Simone da Silva ; Suarez-Mutis, Martha ; Di Santi, Silvia Maria ; Baptista, Andrea Regina de Souza ; Machado, Ricardo Luiz Dantas ; Marinho, Claudio R. F. ; Clark, Taane G. ; Campino, Susana
Número total de Autores: 21
Tipo de documento: Artigo Científico
Fonte: LANCET REGIONAL HEALTH-AMERICAS; v. 18, p. 21-pg., 2023-02-01.
Resumo

Background Brazil is a unique and understudied setting for malaria, with complex foci of transmission associated with human and environmental conditions. An understanding of the population genomic diversity of P. vivax parasites across Brazil can support malaria control strategies.Methods Through whole genome sequencing of P. vivax isolates across 7 Brazilian states, we use population genomic approaches to compare genetic diversity within country (n = 123), continent (6 countries, n = 315) and globally (26 countries, n = 885).Findings We confirm that South American isolates are distinct, have more ancestral populations than the other global regions, with differentiating mutations in genes under selective pressure linked to antimalarial drugs (pvmdr1, pvdhfr-ts) and mosquito vectors (pvcrmp3, pvP45/48, pvP47). We demonstrate Brazil as a distinct parasite population, with signals of selection including ABC transporter (PvABCI3) and PHIST exported proteins.Interpretation Brazil has a complex population structure, with evidence of P. simium infections and Amazonian parasites separating into multiple clusters. Overall, our work provides the first Brazil-wide analysis of P. vivax population structure and identifies important mutations, which can inform future research and control measures.Funding AI is funded by an MRC LiD PhD studentship. TGC is funded by the Medical Research Council (Grant no. MR/M01360X/1, MR/N010469/1, MR/R025576/1, MR/R020973/1 and MR/X005895/1). SC is funded by Medical Research Council UK grants (MR/M01360X/1, MR/R025576/1, MR/R020973/1 and MR/X005895/1) and Blooms-bury SET (ref. CCF17-7779). FN is funded by The Shloklo Malaria Research Unit -part of the Mahidol Oxford Research Unit, supported by the Wellcome Trust (Grant no. 220211). ARSB is funded by Sao Paulo Research Foundation -FAPESP (Grant no. 2002/09546-1). RLDM is funded by Brazilian National Council for Scientific and Technological Development -CNPq (Grant no. 302353/2003-8 and 471605/2011-5); CRFM is funded by FAPESP (Grant no. 2020/06747-4) and CNPq (Grant no. 302917/2019-5 and 408636/2018-1); JGD is funded by FAPESP fellowships (2016/13465-0 and 2019/12068-5) and CNPq (Grant no. 409216/2018-6).Copyright & COPY; 2022 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). (AU)

Processo FAPESP: 02/09546-1 - Epidemiologia e diagnóstico molecular de doenças infecciosas e parasitárias humanas
Beneficiário:Andrea Regina de Souza Baptista
Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
Processo FAPESP: 20/06747-4 - Estudo da resposta imune humoral nas infecções recorrentes por Plasmodium vivax em gestantes da região amazônica
Beneficiário:Cláudio Romero Farias Marinho
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 16/13465-0 - Análise genômica do Plasmodium vivax: identificação de recaídas e associação com efeitos adversos na gravidez em mulheres da Amazônia Brasileira
Beneficiário:Jamille Gregório Dombrowski
Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado Direto
Processo FAPESP: 19/12068-5 - Identificação de biomarcadores preditivos de disfunção placentária na Malária
Beneficiário:Jamille Gregório Dombrowski
Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado