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COVID-19 Vaccination and Serological Profile of a Brazilian University Population

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Barreto, Marina dos Santos ; da Silva, Beatriz Soares ; Santos, Ronaldy Santana ; Silva, Deise Maria Rego Rodrigues ; Silva, Eloia Emanuelly Dias ; Moura, Pedro Henrique Macedo ; de Souza, Jessiane Bispo ; Santana, Lucas Alves da Mota ; Fonseca, Dennyson Leandro M. ; Filgueiras, Igor Salerno ; Guimaraes, Adriana Gibara ; Cabral-Marques, Otavio ; Schimke, Lena F. ; Borges, Lysandro Pinto
Número total de Autores: 14
Tipo de documento: Artigo Científico
Fonte: LIFE-BASEL; v. 13, n. 9, p. 14-pg., 2023-09-01.
Resumo

Background: COVID-19 led to the suspension academic activities worldwide, affecting millions of students and staff. Methods: In this study, we evaluated the presence of IgM and IgG anti-SARS-CoV-2 antibodies in an academic population during the return to classes after a one-year suspension. The study took place over five months at a Brazilian university and included 942 participants. Results: We found that most participants had reactive IgG and non-reactive IgM. All received at least one dose, and 940 received two or more doses, of different COVID-19 vaccines. We obtained a higher average of memory antibodies (IgG) in participants who received the CoronaVac/ChAdOx1 combination. IgG was consistently distributed for each vaccine group, but individuals who completed the vaccination schedule had higher levels. There were no differences between antibodies and gender, presence of symptoms, and previous COVID-19 infection, but older participants (>53 years) and contacts of infected individuals had higher IgM levels. Conclusion: This study makes significant contributions to the assessment of antibodies in the academic environment, allowing us to infer that most participants had memory immunity and low indications of recent infection when returning to face-to-face classes, as well as demonstrating the need to monitor immunity and update vaccinations. (AU)

Processo FAPESP: 18/18886-9 - Análise sistêmica e integrativa da resposta imune às infecções virais por Zika e Dengue
Beneficiário:Otávio Cabral Marques
Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
Processo FAPESP: 20/16246-2 - Caracterização holística do mecanismo de exaustão dos linfócitos T em pacientes com Zika
Beneficiário:Dennyson Leandro Mathias da Fonseca
Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
Processo FAPESP: 23/07806-2 - Fundamentação bioinformática das análises sistêmicas e integrativas de infecções virais.
Beneficiário:Igor Salerno Filgueiras
Modalidade de apoio: Bolsas no Brasil - Programa Capacitação - Treinamento Técnico