| Texto completo | |
| Autor(es): |
Malheiros, Samuel S.
;
Nagay, Bruna E.
;
Bertolini, Martinna M.
;
de Avila, Erica D.
;
Shibli, Jamil A.
;
Souza, Joao Gabriel S.
;
Barao, Valentim A. R.
Número total de Autores: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Expert Review of Medical Devices; v. 20, n. 7, p. 17-pg., 2023-05-31. |
| Resumo | |
IntroductionPeri-implantitis is the leading cause of dental implant loss and is initiated by a polymicrobial dysbiotic biofilm formation on the implant surface. The destruction of peri-implant tissue by the host immune response and the low effectiveness of surgical or non-surgical treatments highlight the need for new strategies to prevent, modulate and/or eliminate biofilm formation on the implant surface. Currently, several surface modifications have been proposed using biomolecules, ions, antimicrobial agents, and topography alterations.Areas coveredInitially, this review provides an overview of the etiopathogenesis and host- and material-dependent modulating factors of peri-implant disease. In addition, a critical discussion about the antimicrobial surface modification mechanisms and techniques employed to modify the titanium implant material is provided. Finally, we also considered the future perspectives on the development of antimicrobial surfaces to narrow the bridge between idea and product and favor the clinical application possibility.Expert opinionAntimicrobial surface modifications have demonstrated effective results; however, there is no consensus about the best modification strategy and in-depth information on the safety and longevity of the antimicrobial effect. Modified surfaces display recurring challenges such as short-term effectiveness, the burst release of drugs, cytotoxicity, and lack of reusability. Stimulus-responsive surfaces seem to be a promising strategy for a controlled and precise antimicrobial effect, and future research should focus on this technology and study it from models that better mimic clinical conditions. (AU) | |
| Processo FAPESP: | 21/09434-0 - Um novo revestimento antimicrobiano para liberação de droga direcionado a dispositivos implantares percutâneos |
| Beneficiário: | Érica Dorigatti de Avila |
| Modalidade de apoio: | Bolsas no Brasil - Jovens Pesquisadores |
| Processo FAPESP: | 22/15677-5 - Síntese de revestimento bi-camada funcionalizado com zinco e complexo quitosana-antibiótico fotoativado para liberação controlada de droga em implantes dentários |
| Beneficiário: | Samuel Santana Malheiros |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |
| Processo FAPESP: | 20/05231-4 - Desenvolvimento de um novo hidrogel termosensitivo para liberação controlada de drogas direcionado a prevenção e ao tratamento de inflamações peri-implantares |
| Beneficiário: | Valentim Adelino Ricardo Barão |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 18/20719-3 - Um novo revestimento antimicrobiano para liberação de droga direcionado a dispositivos implantares percutâneos |
| Beneficiário: | Érica Dorigatti de Avila |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 19/17238-6 - Revestimento antibacteriano com potencial fotocatalítico sob luz visível para implantes dentários: estudos in vitro, in situ e in vivo |
| Beneficiário: | Bruna Egumi Nagay |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |