| Texto completo | |
| Autor(es): |
Martucci, Luiz Felipe
;
Eichler, Rosangela A. S.
;
Silva, Renee N. O.
;
Costa, Tiago J.
;
Tostes, Rita C.
;
Busatto, Geraldo F.
;
Seelaender, Marilia C. L.
;
Duarte, Alberto J. S.
;
Souza, Heraldo P.
;
Ferro, Emer S.
Número total de Autores: 10
|
| Tipo de documento: | Artigo Científico |
| Fonte: | ISCIENCE; v. 26, n. 9, p. 17-pg., 2023-09-15. |
| Resumo | |
Intracellular peptides (InPeps) generated by the orchestrated action of the proteasome and intracellular peptidases have biological and pharmacological sig-nificance. Here, human plasma relative concentration of specific InPeps was compared between 175 patients infected with severe acute respiratory syn-drome coronavirus 2 (SARS-CoV-2), and 45 SARS-CoV-2 non-infected patients; 2,466 unique peptides were identified, of which 67% were InPeps. The results re-vealed differences of a specific group of peptides in human plasma comparing non-infected individuals to patients infected by SARS-CoV-2, following the re-sults of the semi-quantitative analyses by isotope-labeled electrospray mass spectrometry. The protein-protein interactions networks enriched pathways, drawn by genes encoding the proteins from which the peptides originated, re-vealed the presence of the coronavirus disease/COVID-19 network solely in the group of patients fatally infected by SARS-CoV-2. Thus, modulation of the rela-tive plasma levels of specific InPeps could be employed as a predictive tool for disease outcome. (AU) | |
| Processo FAPESP: | 13/08216-2 - CPDI - Centro de Pesquisa em Doenças Inflamatórias |
| Beneficiário: | Fernando de Queiroz Cunha |
| Modalidade de apoio: | Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs |
| Processo FAPESP: | 16/04000-3 - Farmacologia de oligopeptidases e peptídeos intracelulares |
| Beneficiário: | Emer Suavinho Ferro |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 17/25116-2 - Papel da O-GlcNAcilação (O-GlcNAc) na expressão e função do receptor de estrogênio alfa clássico (ERa66kDa) e do splice variant do receptor de estrogênio alfa (ERa36kDa) em artéria carótida comum de camundongos envelhecidos |
| Beneficiário: | Tiago Januário da Costa |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |