Molecular mechanisms and pharmacological interventions in the replication cycle of human coronaviruses

Autor(es)

Simabuco, Fernando Moreira ; Tamura, Rodrigo Esaki ; Betim Pavan, Isadora Carolina ; Morale, Mirian Galliote ; Ventura, Armando Morais

• Tipo de documento: Artigo Científico
• Fonte: GENETICS AND MOLECULAR BIOLOGY; v. 44, n. 1, p. 18-pg., 2021-01-01.

Resumo

SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2), as well as SARS-CoV from 2003 along with MERS-CoV from 2012, is a member of the Betacoronavirus genus of the Nidovirales order and is currently the cause of the pandemic called COVID-19 (or Coronavirus disease 2019). COVID-19, which is characterized by cough, fever, fatigue, and severe cases of pneumonia, has affected more than 23 million people worldwide until August 25th, 2020. Here, we present a review of the cellular mechanisms associated with human coronavirus replication, including the unique molecular events related to the replication transcription complex (RTC) of coronaviruses. We also present information regarding the interactions between each viral protein and cellular proteins associated to known host-pathogen implications for the coronavirus biology. Finally, a specific topic addresses the current attempts for pharmacological interventions against COVID-19, highlighting the possible effects of each drug on the molecular events of viral replication. This review intends to aid future studies for a better understanding of the SARS-CoV-2 replication cycle and the development of pharmacological approaches targeting COVID-19. (AU)

• Processo FAPESP: 16/25139-0 - Proteínas relacionadas à via de sinalização por toll like receptors na tumorigênese desencadeada pelo papilomavírus humano
• Beneficiário: Mirian Galliote Morale
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 19/15619-2 - Desenvolvimento de sistema adenoviral de alta capacidade expressando genes com atividade antitumoral
• Beneficiário: Rodrigo Esaki Tamura
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 18/14818-9 - Estudo de alvos moleculares importantes para o controle do metabolismo em câncer: a via da mTOR/S6K com papel central
• Beneficiário: Fernando Moreira Simabuco
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores - Fase 2
• Processo FAPESP: 20/05346-6 - Estudos de interação entre proteínas celulares e proteínas virais do novo coronavírus de 2019 (SARS-CoV-2)
• Beneficiário: Fernando Moreira Simabuco
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 18/08391-2 - Estudo funcional e molecular da cinase humana NEK6 como alvo de drogas contra Câncer de Próstata
• Beneficiário: Isadora Carolina Betim Pavan
• Modalidade de apoio: Bolsas no Brasil - Doutorado