Is Cortical Activation During Walking Different Between Parkinson's Disease Motor Subtypes?

Autor(es)

Orcioli-Silva, Diego ; Vitorio, Rodrigo ; Beretta, Victor Spiandor ; da Conceicao, Nubia Ribeiro ; Nobrega-Sousa, Priscila ; Oliveira, Anderson Souza ; Bucken Gobbi, Lilian Teresa

• Tipo de documento: Artigo Científico
• Fonte: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES; v. 76, n. 4, p. 7-pg., 2021-04-01.

Resumo

Parkinson's disease (PD) is often classified into tremor dominant (TD) and postural instability gait disorder (PIGD) subtypes. Degeneration of subcortical/cortical pathways is different between PD subtypes, which leads to differences in motor behavior. However, the influence of PD subtype on cortical activity during walking remains poorly understood. Therefore, we aimed to investigate the influence of PD motor subtypes on cortical activity during unobstructed walking and obstacle avoidance. Seventeen PIGD and 19 TD patients performed unobstructed walking and obstacle avoidance conditions. Brain activity was measured using a mobile functional near-infrared spectroscopy-electroencephalography (EEG) systems, and gait parameters were analyzed using an electronic carpet. Concentrations of oxygenated hemoglobin (HbO(2)) of the prefrontal cortex (PFC) and EEG absolute power from alpha, beta, and gamma bands in FCz, Cz, CPz, and Oz channels were calculated. These EEG channels correspond to supplementary motor area, primary motor cortex, posterior parietal cortex, and visual cortex, respectively. Postural instability gait disorder patients presented higher PFC activity than TD patients, regardless of the walking condition. Tremor dominant patients presented reduced beta power in the Cz channel during obstacle avoidance compared to unobstructed walking. Both TD and PIGD patients decreased alpha and beta power in the FCz and CPz channels. In conclusion, PIGD patients need to recruit additional cognitive resources from the PFC for walking. Both TD and PIGD patients presented changes in the activation of brain areas related to motor/sensorimotor areas in order to maintain balance control during obstacle avoidance, being that TD patients presented further changes in the motor area (Cz channel) to avoid obstacles. (AU)

• Processo FAPESP: 17/19845-1 - Análise do sinal eletroencefalográfico em estudos com locomoção
• Beneficiário: Lilian Teresa Bucken Gobbi
• Modalidade de apoio: Auxílio à Pesquisa - Pesquisador Visitante - Internacional
• Processo FAPESP: 14/22308-0 - Efeitos da Doença de Parkinson sobre medidas de eletroencefalografia durante o andar livre e a ultrapassagem de obstáculo
• Beneficiário: Rodrigo Vitório
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado