| Texto completo | |
| Autor(es): |
Silva, Simone S.
;
Rodrigues, Luisa C.
;
Fernandes, Emanuel M.
;
da Costa, Diana Soares
;
Villalva, Denise G.
;
Loh, Watson
;
Reis, Rui L.
Número total de Autores: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | MARINE DRUGS; v. 21, n. 7, p. 15-pg., 2023-07-01. |
| Resumo | |
Emulsion-based systems that combine natural polymers with vegetable oils have been identified as a promising research avenue for developing structures with potential for biomedical applications. Herein, chitosan (CHT), a natural polymer, and virgin coconut oil (VCO), a resource obtained from coconut kernels, were combined to create an emulsion system. Phytantriol-based cubosomes encapsulating sodium diclofenac, an anti-inflammatory drug, were further dispersed into CHT/VCO- based emulsion. Then, the emulsions were frozen and freeze-dried to produce scaffolds. The scaffolds had a porous structure ranging from 20.4 to 73.4 & mu;m, a high swelling ability (up to 900%) in PBS, and adequate stiffness, notably in the presence of cubosomes. Moreover, a well-sustained release of the entrapped diclofenac in the cubosomes into the CHT/VCO-based system, with an accumulated release of 45 & PLUSMN; 2%, was confirmed in PBS, compared to free diclofenac dispersed (80 & PLUSMN; 4%) into CHT/VCO-based structures. Overall, the present approach opens up new avenues for designing porous biomaterials for drug delivery through a sustainable pathway. (AU) | |
| Processo FAPESP: | 19/12665-3 - Biomateriais engenheirados baseados em óleo de coco e polímeros naturais: novas rotas para desenvolvimento de produtos biomédicos com alto valor agregado |
| Beneficiário: | Denise Gradella Villalva |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 21/12071-6 - Arquitetando coloides via interações supramoleculares: de fundamentos a aplicações |
| Beneficiário: | Watson Loh |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 15/25406-5 - Organizando a matéria: colóides formados por associação de surfactantes, polímeros e nanopartículas |
| Beneficiário: | Watson Loh |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 18/08045-7 - Biomateriais engenheirados baseados em óleo de coco e polímeros naturais: novas rotas para desenvolvimento de produtos biomédicos com alto valor agregado |
| Beneficiário: | Watson Loh |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |