Effects of Photobiomodulation with Low-level Laser Therapy on Muscle Repair Following a Peripheral Nerve Injury in Wistar Rats

Autor(es)

Andreo, Lucas ; Ribeiro, Beatriz G. ; Alves, Agnelo N. ; Martinelli, Andreia S. A. ; Soldera, Carla B. ; Horliana, Anna Carolina R. T. ; Bussadori, Sandra Kalil ; Fernandes, Kristianne P. S. ; Mesquita-Ferrari, Raquel A.

• Tipo de documento: Artigo Científico
• Fonte: Photochemistry and Photobiology; v. 96, n. 5, p. 9-pg., 2020-04-23.

Resumo

Peripheral nerve injury (PNI) can lead to sensory and/or motor impairment. As a treatment photobiomodulation (PBM) has demonstrated positive effects in terms of the maintenance of muscle activation and trophism. Wistar rats were divided into five groups: control, injury, injury + PBMn (irradiation over injured nerve), injury + PBMm (irradiation over affected muscle) and injury + PBMnm (irradiation over nerve and muscle). The left sciatic nerve was submitted to a crushing injury. Treatment was administered with low-level laser (780 nm, 0.04 cm(2), 1 W cm(-2), 3.2 J) over the injured nerve and/or the tibialis anterior muscle. The effects of PBM were favorable on muscle morphology and gene expression of calcineurin, myogenin and acetylcholine receptors. PBM led to an acceleration on muscle repair process, and effects were more evident in 2 weeks after PNI. Thus, PBM is indicated for the area over both the injured nerve and the affected muscle. (AU)

• Processo FAPESP: 14/12381-1 - Análise comparativa do efeito da laserterapia prévia associada ou não ao tratamento pós sobre a modulação de citocinas inflamatórias, do estresse oxidativo e a determinação do tipo de fibra muscular após lesão aguda
• Beneficiário: Raquel Agnelli Mesquita Ferrari
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/07502-1 - Efeito da laserterapia sobre a expressão gênica e a produção de citocinas, quimiocinas e fatores de crescimento envolvidos no reparo muscular
• Beneficiário: Kristianne Porta Santos Fernandes
• Modalidade de apoio: Auxílio à Pesquisa - Regular