Application of Lipidomics in Psychiatry: Plasma-Based Potential Biomarkers in Schizophrenia and Bipolar Disorder

Autor(es)

Costa, Alana C. ; Rica, Larissa B. ; van de Bilt, Martinus ; Zandonadi, Flavia S. ; Gattaz, Wagner F. ; Talib, Leda L. ; Sussulini, Alessandra

• Tipo de documento: Artigo Científico
• Fonte: METABOLITES; v. 13, n. 5, p. 15-pg., 2023-04-27.

Resumo

In this study, we obtained a lipidomic profile of plasma samples from drug-naive patients with schizophrenia (SZ) and bipolar disorder (BD) in comparison to healthy controls. The sample cohort consisted of 30 BD and 30 SZ patients and 30 control individuals. An untargeted lipidomics strategy using liquid chromatography coupled with high-resolution mass spectrometry was employed to obtain the lipid profiles. Data were preprocessed, then univariate (t-test) and multivariate (principal component analysis and orthogonal partial least squares discriminant analysis) statistical tools were applied to select differential lipids, which were putatively identified. Afterward, multivariate receiver operating characteristic tests were performed, and metabolic pathway networks were constructed, considering the differential lipids. Our results demonstrate alterations in distinct lipid pathways, especially in glycerophospholipids, sphingolipids and glycerolipids, between SZ and BD patients. The results obtained in this study may serve as a basis for differential diagnosis, which is crucial for effective treatment and improving the quality of life of patients with psychotic disorders. (AU)

• Processo FAPESP: 14/50867-3 - INCT 2014: Instituto Nacional de Ciência e Tecnologia de Bioanalítica
• Beneficiário: Marco Aurelio Zezzi Arruda
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 14/50873-3 - INCT 2014: Instituto Nacional de Biomarcadores em Neuropsiquiatria (INBioN)
• Beneficiário: Wagner Farid Gattaz
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 18/01525-3 - Estudos metabolômicos de pacientes com depressão tratados com ayahuasca
• Beneficiário: Alessandra Sussulini
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/26291-2 - Marcadores periféricos de metabolismo de membrana: caracterização de indivíduos com alto risco para psicose
• Beneficiário: Alana Caroline Costa
• Modalidade de apoio: Bolsas no Brasil - Doutorado