Novel Gadolinium-Free Ultrasmall Nanostructured Positive Contrast for Magnetic Resonance Angiography and Imaging

Autor(es)

Kawassaki, Rodrigo Ken ; Romano, Mariana ; Uchiyama, Mayara Klimuk ; Cardoso, Roberta Mansini ; Baptista, Mauriicio S. ; Farsky, Sandra H. P. ; Chaim, Khallil Taverna ; Guimaraes, Robson Raphael ; Araki, Koiti

• Tipo de documento: Artigo Científico
• Fonte: Nano Letters; v. 23, n. 12, p. 9-pg., 2023-06-10.

Resumo

Nanostructured contrast agents are promising alternativesto Gd3+-based chelates in magnetic resonance (MR) imagingtechniques.A novel ultrasmall paramagnetic nanoparticle (UPN) was strategicallydesigned to maximize the number of exposed paramagnetic sites and r (1) while minimizing r (2), by decorating 3 nm titanium dioxide nanoparticles with suitableamounts of iron oxide. Its relaxometric parameters are comparableto those of gadoteric acid (GA) in agar phantoms, and the r (2)/r (1) ratio of 1.38at 3 T is close to the ideal unitary value. The strong and prolongedcontrast enhancement of UPN before renal excretion was confirmed by T (1)-weighted MR images of Wistar rats after intravenousbolus injection. Those results associated with good biocompatibilityindicate its high potential as an alternative blood-pool contrastagent to the GA gold standard for MR angiography, especially for patientswith severe renal impairment. (AU)

• Processo FAPESP: 09/54323-0 - Plataforma de imagem na sala de autópsia
• Beneficiário: Paulo Hilário Nascimento Saldiva
• Modalidade de apoio: Auxílio à Pesquisa - Programa Equipamentos Multiusuários
• Processo FAPESP: 18/21489-1 - Nanotecnologia supramolecular: design, materiais e dispositivos
• Beneficiário: Henrique Eisi Toma
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 19/02151-2 - Desenvolvimento de nanoagente teranóstico bimodal para MRI e PET/SPECT
• Beneficiário: Rodrigo Ken Kawassaki
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto