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Antimicrobial peptides as drugs with double response against Mycobacterium tuberculosis coinfections in lung cancer

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Autor(es):
Polinario, Giulia ; Primo, Laura Maria Duran Gleriani ; Rosa, Maiara Alane Baraldi Cerquetani ; Dett, Freddy Humberto Marin ; Barbugli, Paula Aboud ; Roque-Borda, Cesar Augusto ; Pavan, Fernando Rogerio
Número total de Autores: 7
Tipo de documento: Artigo Científico
Fonte: FRONTIERS IN MICROBIOLOGY; v. 14, p. 17-pg., 2023-06-02.
Resumo

Tuberculosis and lung cancer are, in many cases, correlated diseases that can be confused because they have similar symptoms. Many meta-analyses have proven that there is a greater chance of developing lung cancer in patients who have active pulmonary tuberculosis. It is, therefore, important to monitor the patient for a long time after recovery and search for combined therapies that can treat both diseases, as well as face the great problem of drug resistance. Peptides are molecules derived from the breakdown of proteins, and the membranolytic class is already being studied. It has been proposed that these molecules destabilize cellular homeostasis, performing a dual antimicrobial and anticancer function and offering several possibilities of adaptation for adequate delivery and action. In this review, we focus on two important reason for the use of multifunctional peptides or peptides, namely the double activity and no harmful effects on humans. We review some of the main antimicrobial and anti-inflammatory bioactive peptides and highlight four that have anti-tuberculosis and anti-cancer activity, which may contribute to obtaining drugs with this dual functionality. (AU)

Processo FAPESP: 22/09728-6 - Avaliação da atividade contra Mycobacterium tuberculosis resistente de nanopartículas de N-acetilcisteína-quitosana conjugada com o peptídeo antimicrobiano Ctx(Ile21)-Ha-Ahx-Cys carregada com rifampicina.
Beneficiário:Laura Maria Duran Gleriani Primo
Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
Processo FAPESP: 20/16573-3 - Estudos in vitro e in vivo de análogos do peptídeo antimicrobiano B1CTcu5 encapsulados em micropartículas colón-específicas frente ao Mycobacterium tuberculosis
Beneficiário:Cesar Augusto Roque Borda
Modalidade de apoio: Bolsas no Brasil - Doutorado
Processo FAPESP: 20/13497-4 - Busca do mecanismo de ação e efeito terapêutico de novas classes de fármacos contra Mycobacterium tuberculosis
Beneficiário:Fernando Rogério Pavan
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 21/14603-5 - Descoberta e desenho de fármacos: análogos do peptídeo antimicrobiano B1CTcu5 promissores contra o Mycobacterium tuberculosis
Beneficiário:Cesar Augusto Roque Borda
Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado