Thermal analysis of tetracyclines: a review

Autor(es)

de Freitas, Jonatha ; Ferreira, Ana Paula Garcia ; Cavalheiro, Eder Tadeu Gomes

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY; v. N/A, p. 13-pg., 2023-06-24.

Resumo

A revision on articles concerning thermal analysis of tetracyclines is presented, regarding drug-excipient compatibility, characterization of drug releasing systems, physicochemical behavior of drug-supported systems and degradation of some pharmaceuticals itself. Initially, an overview of information regarding this class of drugs is presented. A bibliographic survey revealed relatively few works on this subject despite the worldwide use and relevance of this class of antibiotics. Here, 37 papers published during the time frame 2000-2022 were classified as above and discussed once they presented thermoanalytical data straightly related to the tetracyclines. From the thermal studies of the drugs, a general decomposition behavior could be identified and it is presented. (AU)

• Processo FAPESP: 19/22217-8 - Estudos termoanalíticos aplicados a fármacos antivirais antihepatite e antiretrovirais da classe dos inibidores de protease: comportamento térmico, intermediários de decomposição, caracterização de voláteis e polimorfismo
• Beneficiário: Éder Tadeu Gomes Cavalheiro
• Modalidade de apoio: Auxílio à Pesquisa - Regular