1H NMR Metabolomics and Lipidomics To Monitor Positive Responses in Children with Autism Spectrum Disorder Following a Guided Parental Intervention: A Pilot Study

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Correia, Banny Silva Barbosa ; Pontes, Joao Guilherme de Moraes ; Nani, Joao Victor Silva ; Villalta, Fabian ; Mor, Natalia Cristina ; Bordini, Daniela ; Brunoni, Decio ; Brentani, Helena ; Mari, Jair Jesus ; Hayashi, Mirian A. F. ; Tasic, Ljubica

• Tipo de documento: Artigo Científico
• Fonte: ACS Chemical Neuroscience; v. 14, n. 6, p. 9-pg., 2023-02-21.

Resumo

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition that is characterized by patients displaying at least two out of the classical symptoms, such as impaired social communication, impaired interactions, and restricted repeti t i v e behavior. Early parent-mediated interventions, such as video modeling for parental training, were demonstrated to be a successf u l low-cost way to del i v e r care for children with ASD. Nuclear magnetic resonance (NMR)-based metabolomics/lipidomics has been success-fully employed in several mental disorder studies. Metabolomics and lipidomics of 37 ASD patients (children, aged 3-8 years), who were divided into two groups, one control group with no parental-training intervention (N = 18) and the other in which the parents were trained by a video modeling intervention (ASD parental training, N = 19), were analyzed by proton NMR spectroscopy. Patients in the ASD parental-training group sera were seen to have increased glucose, myo-inositol, malonate, prol i n e , phenylalanine, and gangliosides in their blood ser u m , while cholesterol, choline, and lipids were decreased, compared to the control group, who received no parental-training. Taken together, we demonstrated here significant changes in serum metabolites and lipids in ASD children, previously demonstrated to show clinical positive efl'ects following a parental training intervention based on video modeling, delivered over 22 weeks. We demonstrate the value of applying metabolomics and lipidomics to identify potential biomarkers for clinical interventions follow-up in ASD. (AU)

• Processo FAPESP: 19/09207-3 - Estudo do(s) mecanismo(s) molecular(es) e celular(es) em transtornos mentais
• Beneficiário: João Victor Silva Nani
• Modalidade de apoio: Bolsas no Brasil - Doutorado
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• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 14/50867-3 - INCT 2014: Instituto Nacional de Ciência e Tecnologia de Bioanalítica
• Beneficiário: Marco Aurelio Zezzi Arruda
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 19/13112-8 - Estudo dos mecanismos moleculares e celulares em transtornos mentais: estudos clínicos e modelos animais
• Beneficiário: Mirian Akemi Furuie Hayashi
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 20/01107-7 - Estudo para otimização do uso da crotamina como teranóstico na terapia de doenças humanas: câncer, síndrome metabólica e disfunções renais
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• Modalidade de apoio: Auxílio à Pesquisa - Regular