Harnessing the Power of Venomous Animal-Derived Toxins against COVID-19

Autor(es)

Oliveira, Isadora ; Ferreira, Isabela ; Jacob, Beatriz ; Cardenas, Kiara ; Cerni, Felipe ; Baia-da-Silva, Djane ; Arantes, Eliane ; Monteiro, Wuelton ; Pucca, Manuela

• Tipo de documento: Artigo Científico
• Fonte: TOXINS; v. 15, n. 2, p. 12-pg., 2023-02-01.

Resumo

Animal-derived venoms are complex mixtures of toxins triggering important biological effects during envenomings. Although venom-derived toxins are known for their potential of causing harm to victims, toxins can also act as pharmacological agents. During the COVID-19 pandemic, there was observed an increase in in-depth studies on antiviral agents, and since, to date, there has been no completely effective drug against the global disease. This review explores the crosstalk of animal toxins and COVID-19, aiming to map potential therapeutic agents derived from venoms (e.g., bees, snakes, scorpions, etc.) targeting COVID-19. (AU)

• Processo FAPESP: 20/13176-3 - Descoberta de anticorpos monoclonais humanos (scFv) com reatividade cruzada e pH-dependentes para as metaloproteases de Bothrops spp
• Beneficiário: Isadora Sousa de Oliveira
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 21/11936-3 - Centro de Ciência Translacional e Desenvolvimento de Biofármacos
• Beneficiário: Benedito Barraviera
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Ciência para o Desenvolvimento
• Processo FAPESP: 19/10173-6 - Produção, modificação e caracterização de toxinas animais com potencial aplicação biotecnológica
• Beneficiário: Eliane Candiani Arantes Braga
• Modalidade de apoio: Auxílio à Pesquisa - Regular